Description
Caripazym Pharmacodynamics
Caripazim is made from Prokaripazim dry extract obtained from dried milky juice of immature fruits of melon tree (papaya L., family Caricaceae) by dissolving the dry extract in water for injection, followed by sterile filtration of the solution and freeze-drying.
Chemically, the drug is a sum of water-soluble proteolytic enzymes, the active components of which are the following enzymes: papain, chymopapain A, chymopapain B, peptidase A, peptidase B.
It has proteolytic activity. The drug splits necrotic tissues, liquefies viscous secretions, exudates, blood clots. By its action, it is similar to lecosyme and its components.
Indications
III-degree burns (to accelerate plaque detachment and cleaning of wound surfaces from residual purulent-necrotic tissues.
Contraindications .
Hypersensitivity to the components of the drug. Pregnancy, lactation.
Dosage and administration
- Outwardly, as a 0.5%, 1% or 2% solution, depending on the thickness of the crust.
- The solutions are prepared using 0.5% novocaine or 0.9% (physiological) sodium chloride solution.
- To prepare 0.5%, 1% or 2% solution of the drug the contents of the bottle is diluted with 20 ml, 10 ml or 5 ml of novocaine or sodium chloride solution respectively. The drug solutions shall be used immediately after preparation.
- A napkin soaked in the drug solution is applied to the burned surface and covered with moisture-proof dressing.
- No more than 30% of the total body surface is treated at a time.
- The dressing is changed once a day or once every two days, while removing the detached necrotic tissue.
- The course of treatment is 4 to 12 days.
