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Omeprazole (Ultop) 20 mg – [14 capsules]

$12.42

Gastric gland secretion reducing agent – proton pump inhibitor

SKU: 63067 Category:

Description

Ultop Pharmacodynamics
Inhibits the enzyme H+-K+-ATPase (proton pump) in the parietal cells of the stomach and thus blocks the final stage of hydrochloric acid synthesis. This leads to a decrease in basal and stimulated secretion, regardless of the nature of the stimulus. After a single oral dose, the effect of omeprazole occurs within the first hour and lasts for 24 hours, the maximum effect being reached after 2 hours.
In patients with duodenal ulcer disease, administration of 20 mg of omeprazole maintains intragastric pH at 3 for 17 h. After discontinuation of the drug, secretory activity is fully restored after 3-5 days.

Indications
– Gastric and duodenal ulcer (acute phase and contraciliation treatment), including those associated with Helicobacter pylori (in combination therapy);
– gastroesophageal reflux disease (GERD), including reflux esophagitis and non-erosive forms of reflux disease (NERD);
– gastric and duodenal erosive ulcers associated with taking NSAIDs, stress ulcers;
– Zollinger-Ellison syndrome and other pathological conditions associated with increased gastric secretion.

Contraindications
– Hypersensitivity to omeprazole or other components of the drug;
– childhood;
– pregnancy;
– lactation.

Dosage and administration

  • Orally, before a meal with plain water (capsule contents should not be chewed).
  • Gastric ulcer in acute phase – 20 mg/day for 2-4 weeks (in resistant cases – up to 40 mg/day).
  • Peptic ulcer in acute phase and erosive-ulcerous esophagitis – 20-40 mg/d for 4-8 weeks.
  • Gastroesophageal reflux disease (GERD): patients with moderate inflammation – 1 capful (20 mg) 1 time per day in the morning, before breakfast, for 4-8 weeks. To ensure the dosing regimen below, it is possible to take the drug in another registered dosage (Ultop® 40 mg capsules). Patients with severe GERD resistant to conventional therapy – 40 mg once daily, before breakfast. Duration of basic course is usually 4-8 weeks. After healing of erosive esophagitis it is shown maintenance treatment during 26-52 weeks, in severe esophagitis – for life.
  • Gastrointestinal erosive and ulcerative lesions caused by taking NSAIDs – 20 mg/day during 4-8 weeks.
  • Eradication of Helicobacter pylori – 20 mg 2 times per day for 7 or 14 days (depending on the treatment regimen) in combination with antibacterial agents.
  • Antiretroviral treatment of gastric and duodenal ulcer – 10-20 mg/day.
  • Antiretroviral treatment of reflux esophagitis – 20 mg/d for a long time. On-demand administration is possible.
  • Zollinger-Ellison syndrome – the dose is selected individually depending on the initial level of gastric secretion, usually starting with 60 mg/day. If necessary, the dose is increased to 80-120 mg/day, in which case it is divided into 2 doses.
  • In patients with severe hepatic insufficiency, the daily dose should not exceed 20 mg.