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Norfloxacin 400 mg – [20 tablets]


Antibacterial drug of the fluoroquinolone group

SKU: 62274 Category:


Norfloxacin Pharmacodynamics
An antimicrobial agent of the group of fluoroquinolones. It has a bactericidal effect. It affects the bacterial enzyme DNA-gyrase, which provides superspiralization and thus stability of bacterial DNA. Destabilization of DNA chain leads to the death of bacteria. It has a wide range of antibacterial action. Active under in vitro and in vivo conditions against the following microorganisms: Gram-positive aerobes – Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus, Streptococcus agalactiae; Gram-negative aerobes – Citrobacter freundii, Enterobacter aerogenes, Enterobacter cloacae, Escherichia coli, Klebsiella pneumoniae, Neisseria gonorrhoeae, Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa, Serratia marcescens, Salmonella spp. , Shigella spp.
Sensitive in vitro: Gram-negative aerobes – Citrobacter diversus, Edwardsiella tarda, Enterobacter agglomerans, Elaemophilus ducreyi, Klebsiella oxytoca, Morganella morganii, Providencia alcalifaciens, Providencia rettgeri, Providencia stuartii, Pseudomonas fluorescens, Pseudomonas stutzeri; others – Ureaplasma urealyticum.
Inactive against obligate anaerobes.

Infectious-inflammatory diseases caused by microorganisms sensitive to norfloxacin:
– complicated urinary tract infections;
– Chronic bacterial prostatitis.
For the treatment of the following infections and inflammatory diseases, norfloxacin can be used only as an alternative to other antimicrobial agents:
– Uncomplicated urinary tract infections.
When using Norfloxacin, official national recommendations for appropriate use of antibacterial agents as well as sensitivity of pathogenic microorganisms in a particular country should be taken into account.

– Hypersensitivity to norfloxacin, excipients of the drug and other quinolones;
– glucose-6-phosphate dehydrogenase deficiency;
– tendinitis, tendovaginitis, tendon rupture associated with taking fluoroquinolones (including anamnesis);
– hereditary lactose intolerance, lactase deficiency or glucose-galactose malabsorption;
– Childhood and adolescence (under 18 years);
– Pregnancy and breastfeeding.

Dosage and administration

  • Orally on an empty stomach (not less than 1 hour before and not earlier than 2 hours after a meal), with plenty of fluids.
  • In complicated urinary tract infections it is prescribed on 400 mg 2 times daily during 10-21 days.
  • In chronic bacterial prostatitis it is prescribed 400 mg 2 times a day for 4 weeks or longer.
  • In uncomplicated urinary tract infections in men it is prescribed 400 mg 2 times daily for 7-14 days.
  • In acute uncomplicated cystitis in women it is prescribed 400 mg 2 times daily for 3-7 days.
  • Dosage regimen adjustment is not required for patients with impaired renal function and creatinine clearance greater than 30 ml/min.
  • In patients with creatinine clearance less than 30 ml/min (or serum creatinine concentration more than 5 mg/100 ml) and in patients on hemodialysis half of the dose of
  • Norfloxacin 2 times a day or full dose of Norfloxacin once a day is administered.
  • No dose adjustment is required for patients on continuous ambulatory peritoneal dialysis with preserved diuresis.