Description
Nitrofural (Furacilin) solution Pharmacodynamics
Antimicrobial agent, nitrofuran derivative. Bacterial flavoproteins, by reducing the 5-nitro group, form highly reactive amino derivatives that can cause conformational changes in proteins (including ribosomal) and other macromolecules, leading to the death of bacteria. Active against Gram-positive and Gram-negative bacteria (Staphylococcus spp. Streptococcus spp., Escherichia coli, Clostridium perfringens).
Resistance develops slowly and does not reach a high degree.
Indications
Externally: purulent wounds, bedsores, II-III degree burns, minor skin injuries (including abrasions, scratches, cracks, cuts).
Topically: blepharitis, conjunctivitis, osteomyelitis, sinus and pleural empyema – cavity lavage, acute tonsillitis, stomatitis, gingivitis.
Contraindications
Hypersensitivity to nitrofural, nitrofuran derivatives and / or other components of Nitrofural (Furacilin) solution , bleeding, allergic dermatosis.
Pregnancy and lactation:
There are no data on possible adverse effects of the drug on the health of a pregnant woman or child.
However, during pregnancy and breast-feeding the drug should be used only after consultation with the physician if the expected benefits to the mother exceed the potential risk to the fetus and the child.
Directions for use and dosages
- Topically, externally.
- Topically. Irrigate purulent wounds, bedsores, II-III degree burns, minor skin injuries (including abrasions, scratches, cracks, cuts) and put on wet dressings.
- Topically. Intracavitary: in maxillary sinusitis – washing of the maxillary cavity; in osteomyelitis after surgery – washing of the cavity with subsequent damp dressing; pleural empyema – after removal of pus wash into pleural cavity and administer 20-100 ml of water solution;
- Blepharitis, conjunctivitis – instillation of aqueous solution into the conjunctival sac.
- In acute tonsillitis, stomatitis, gingivitis – mouth and throat rinse with 100 ml 2-3 times a day.
- Duration of the course of treatment according to indications depending on the nature and localization of the affected area.