Description
Nifuroxazide Pharmacodynamics
Nifuroxazide is an antimicrobial agent derived from nitrofuran. It blocks activity of dehydrogenases and inhibits respiratory chain, tricarboxylic acid cycle and a number of other biochemical processes in a microbial cell. It destroys the membrane of the microbial cell and reduces the production of toxins by microorganisms.
Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp, Shigella spp; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp.
Weakly sensitive to nifuroxazide: Citrobacter spp, Enterobacter cloacae and Proteus indologenes.
Resistant to Nifuroxazide: Klebsiella spp, Proteus mirabilis, Providencia spp, Pseudomonas spp.
Nifuroxazide does not disturb the balance of intestinal microflora. In acute bacterial diarrhea it restores intestinal eubiosis. In case of infection with enterotropic viruses it prevents development of bacterial superinfection.
Indications
Acute bacterial diarrhea without a deterioration of the general condition, fever and intoxication.
Contraindications
– Hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug;
– fructose intolerance, glucose-galactose malabsorption syndrome or insufficiency of sucrose and isomaltase;
– pregnancy;
– Children under 3 years of age.
Use in pregnancy and during breast-feeding:
No teratogenic effects have been observed in animal studies. However, as a precautionary measure, it is not recommended to take nifuroxazide during pregnancy.
During the lactation period it is possible to continue breastfeeding in case of a short course of treatment with the drug. It is necessary to consult a physician.
Dosage and administration
- Used orally. The capsule should be swallowed whole with a small amount of water.
100 mg capsules - Children aged 3 to 6 years: 200 mg (2 capsules) 3 times a day (8 hours between doses), the daily dose is 600 mg.
- Children 6 to 18 years of age: 200 mg (2 capsules) 3 to 4 times a day (interval between doses of 6-8 hours), the daily dose is 600-800 mg.
- Adults: 200 mg (2 capsules) 4 times a day (6-hour interval between doses), the daily dose is 800 mg.
- The course of treatment is 5-7 days, but no more than 7 days.
- If during the first 3 days of treatment there was no improvement, you should consult a doctor.
- Use the drug only according to the method of use and in those doses that are specified in the instructions.
- If necessary, please consult a physician before using the drug.
