Description
Sanorin Pharmacodynamics
Nafazolin belongs to alpha2-adrenomimetics with direct stimulating effect on alpha-adrenoreceptors of sympathetic nervous system. When administered intranasally it has a rapid, pronounced and prolonged vasoconstrictor effect on vessels of nasal mucous membranes, nasopharynx and sinus cavities – it reduces swelling and hyperemia, thus improving nasal passageway and facilitating nasal breathing. At the same time the patency of the eustachian tubes is restored. Therapeutic effect usually occurs within 5 minutes after drug administration and lasts for 4-6 hours.
Indications
– Acute rhinitis of various etiologies;
– otitis media – as an additional means to reduce nasopharyngeal mucosal edema;
– sinusitis;
– Eustachyitis;
– laryngitis;
– to reduce swelling of the mucous membranes of the nose, nasopharynx and sinuses during diagnostic and therapeutic procedures;
– If necessary to stop nasal bleeding.
Contraindications
– Hypersensitivity to the drug components;
– chronic rhinitis;
– atrophic rhinitis;
– closed-angle glaucoma;
– severe eye disease;
– arterial hypertension;
– marked atherosclerosis;
– tachycardia;
– hyperthyroidism;
– diabetes mellitus;
– concomitant use of monoamine oxidase inhibitors and up to 14 days after the end of their use.
SANORIN® 0.05% solution is contraindicated in children under 2 years of age.
SANORIN® 0.1% solution is contraindicated in children under 15 years of age.
Caution
Pregnancy, lactation, coronary heart disease (angina pectoris), prostatic hyperplasia, pheochromocytoma.
Pregnancy and lactation
There are no data on penetration of naphazolin through the placental barrier, as well as in breast milk. Therefore, when prescribing the drug, it is necessary to correlate the possible risk for the child and fetus with the expected therapeutic effect for the mother.
Directions for use and dosages
- Intranasally.
- Adults and children over 15 years of age:
- 1 to 3 drops of 0.1% solution of SANORIN® in each nasal passage 3-4 times a day.
- Children 2-15 years old:
- 1-2 drops of 0.05% SANORIN® solution in each nasal passage 2-3 times a day with an interval of at least 4 hours.
- Use for a short period of time, not more than 1 week in adults and not more than 3 days in children.
- If nasal breathing becomes easier, the use of SANORIN® may be terminated earlier. Re-application is possible after a few days.
- In case of nasal bleeding, a cotton swab moistened with 0.05% SANORIN® solution may be placed in the nasal passage.
- At rhinoscopy for prolongation of surface anesthesia: 2-4 drops of 0.1% solution with 1 ml of anesthetic.
- The drug is injected into each nasal passage with the head slightly tilted back. When injecting into the left nasal passage the head should be tilted to the right and when injecting into the right nasal passage the head should be tilted to the left.
