Description
Naftoderil Pharmacodynamics
Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is related to the inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus.
It is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, mold fungi (Aspergillus spp.), yeast fungi (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii).
Against dermatophytes and aspergillus naphthifin acts fungicidal.
Against yeast fungi naphthifin has fungicidal or fungistatic activity depending on the strain of the microorganism.
It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections.
It has anti-inflammatory activity, which contributes to the rapid disappearance of inflammatory symptoms, especially itching.
Indications
– Fungal infections of the skin and skin folds (tinea corporis, tinea inquinalis);
– Interfinger mycoses (tinea manum, tinea pedum);
– Fungal infections of the nails (onychomycoses);
– skin candidiasis;
– Lichen multicolor (pityriasis);
– dermatomycoses (with or without associated itching).
Naftoderil drug is effective in the treatment of mycoses affecting areas of the skin with hyperkeratosis, as well as in hair growth areas.
Contraindications
– Hypersensitivity to naphthifin or other components of the drug;
– Pregnancy and breast-feeding (safety and efficacy of use have not been established).
– Application to the wound surface.
Caution:
Childhood (experience with clinical use is limited).
Use during pregnancy and during breast-feeding:
The use of the drug during pregnancy and during breastfeeding is contraindicated (safety and efficacy of naftifin in this category of patients has not been studied).
Directions for use and dosages.
- Outwardly.
- In case of skin lesions.
- Naftoderil drug is applied once a day to the affected skin surface and adjoining areas (approximately 1 cm of healthy skin edge) after thorough cleaning and drying.
- Duration of therapy with dermatomycosis – 2-4 weeks (if necessary up to 8 weeks), with candidiasis – 4 weeks.
- When nails are affected.
- Naftoderil drug is applied 2 times a day to the affected nail. Before the first use of the drug as much as possible remove the affected part of the nail with scissors or a nail file.
- The duration of therapy for onychomycosis is up to 6 months.
- To prevent relapse, treatment should be continued for at least 2 weeks after the disappearance of clinical symptoms.
- If after treatment no improvement occurs or symptoms worsen, or new symptoms appear, consult a doctor. Use the drug only according to the method of application and in the doses stated in the instructions. If necessary, please consult a physician before using the drug.
