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Naftifine (Mycoderil) 1% – [30 ml vial]


Antifungal drug for external use

SKU: 62097 Category:


Mycoderil Pharmacodynamics
Mycoderil® is an antifungal drug for external use, the active ingredient of which is naphthifine. Naphtifine is an antifungal agent belonging to the class of alilamines. The mechanism of action is associated with inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. Naftifine, affecting squalene epoxidase, does not affect the cytochrome P-450 system.
Naphtifine is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, yeast and yeast-like fungi (Candida spp., Pityrosporum), mold fungi (Aspergillus) and other fungi (e.g. Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi the drug has fungicidal or fungistatic activity depending on the strain of the microorganism. Naftifin has antibacterial activity against Gram-positive and Gram-negative microorganisms causing secondary bacterial infections.
Naphtifine has anti-inflammatory activity, which contributes to the rapid disappearance of inflammatory symptoms, especially itching.

– Fungal infections of smooth skin and skin folds (tinea corporis, tinea inquinalis);
– Interfinger mycoses (tinea manum, tinea pedum);
– Fungal infections of the nails (onychomycoses);
– skin candidiasis;
– pityriasis;
– inflammatory dermatomycoses (with or without itching).

Hypersensitivity to naphthyphine or propylene glycol; pregnancy and lactation period (safety and efficacy of the drug in this category of patients has not been studied).
Application of the drug to the wound surface is contraindicated.
Childhood (experience of clinical use is limited).
Administration during pregnancy and lactation
It is not recommended to use the drug during pregnancy and breast feeding. Safety and effectiveness of the drug in this group of patients has not been studied.

Dosage and administration method.

  • Outwardly.
  • In dermatomycosis and candidiasis of the skin.
  • Mycoderil®, solution for external use, 1% is applied once a day to the affected skin surface and adjoining areas after thorough cleaning and drying, leaving approximately 1 cm of healthy skin at the edge of the affected area. Duration of treatment: in dermatomycosis – 2-4 weeks (if necessary – up to 8 weeks), with candidiasis – 4 weeks.
  • With lesions of the nails (onychomycosis).
  • Before the first use of the drug, remove the affected part of the nail with scissors and a nail file as much as possible. The drug is used 2 times a day, the duration of treatment for onychomycosis is up to 6 months. To prevent recurrence of the infection the drug should be continued for at least 2 weeks after the disappearance of clinical symptoms.