Description
Mizol-Evalar Pharmacodynamics
Naftifin is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is related to the inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is part of the cell wall of the fungus. It is active against dermatophytes such as Trichophyton, Epidermophyton and Microsporum, molds (Aspergillus spp.), yeasts (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi the drug exhibits fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections. It has anti-inflammatory activity, which contributes to the rapid disappearance of inflammatory symptoms, especially itching.
Indications
– Fungal infections of the skin and skin folds (tinea corporis, tinea inguinalis);
– Interfinger mycoses (tinea manum, tinea pedum);
– Fungal infections of the nails (onychomycoses);
– skin candidiasis;
– Lichen multicolor (pityriasis);
– Dermatomycoses (with or without associated itching).
Contraindications
Hypersensitivity to naphthifin or propylene glycol.
Pregnancy and breastfeeding (safety and efficacy of use have not been established).
Application of the drug to the wound surface is contraindicated.
Caution
Childhood (experience of clinical use is limited).
Administration during pregnancy and lactation
During pregnancy and breast-feeding, application of Mizol® Evalar is contraindicated (safety and efficacy of naphthifin has not been studied in this group of patients).
Dosage and administration method
- Outwardly.
- Mizol® Evalar is applied once a day to the affected skin surface and its neighbors (about 1 cm of healthy skin edge) after its thorough cleaning and drying. Duration of therapy with dermatomycosis – 2-4 weeks (if necessary – up to 8 weeks), with candidiasis – 4 weeks.
- When affecting the nails, Mizol® Evalar is applied 2 times a day to the affected nail.
- Before the first use of the drug, remove the affected part of the nail with scissors or a nail file as much as possible. The duration of therapy for onychomycosis is up to 6 months.
- To prevent relapse, treatment should be continued for at least 2 weeks after the disappearance of clinical symptoms.
- If there is no improvement or new symptoms appear after treatment, consult a doctor.
- Use the drug only according to the method of use and in such doses as specified in the instructions. If necessary, please consult a physician before using the drug.
