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Description
Naftifine (Fungoderil) 1% Pharmacodynamics
Naftifine is an antifungal agent for external use, belonging to the class of allilamines. The mechanism of action is related to the inhibition of squalene-2,3-epoxidase, which leads to a decrease in the formation of ergosterol, which is a part of the cell wall of the fungus.
It is active against dermatophytes such as Trichophyton, Epidermophyton, Microsporum, mold fungi (Aspergillus spp.), yeast fungi (Candida spp., Pityrosporum) and other fungi (such as Sporothrix schenckii). Against dermatophytes and aspergillus naphthifin acts fungicidal. Against yeast fungi naphthifin has fungicidal or fungistatic activity depending on the strain of the microorganism. It has antibacterial activity against Gram-positive and Gram-negative microorganisms that can cause secondary bacterial infections.
It has anti-inflammatory activity, which contributes to the rapid disappearance of inflammatory symptoms, especially itching.
Indications
– Fungal infections of the skin and skin folds (tinea corporis, tinea inquinalis);
– Interfinger mycoses (tinea manum, tinea pedum);
– Fungal infections of the nails (onychomycoses);
– skin candidiasis;
– Lichen multicolor (pityriasis);
– Dermatomycoses (with or without associated itching).
Contraindications
Hypersensitivity to Naftifine or other components of Naftifine (Fungoderil) 1% ; pregnancy and lactation (safety and efficacy of use have not been established), application on the wound surface.
Caution
Childhood (experience of clinical use is limited).
Administration during pregnancy and lactation
It is contraindicated in pregnancy and during breast-feeding (safety and efficacy of naftifin has not been studied in this group of patients).
Directions for use and dosages
Externally.
In case of skin lesions
It is applied once a day to the affected skin surface and adjoining areas (about 1 cm of healthy skin edge) after their thorough cleaning and drying.
Duration of therapy with dermatomycosis – 2-4 weeks (if necessary up to 8 weeks), with candidiasis – 4 weeks.
In case of nails affection.
It is applied to the affected nail. Before the first use of Naftifine (Fungoderil) 1% , remove the affected part of the nail with a pair of scissors or a nail file as much as possible.
The duration of therapy for onychomycosis is up to 6 months.
To prevent relapse, treatment should be continued for at least 2 weeks after the disappearance of clinical symptoms.
