Description
Minolecsin Pharmacodynamics
It is an antibiotic of tetracycline group. It has a bacteriostatic effect due to inhibition of protein synthesis by reversible binding to 30S ribosomal subunit of susceptible microorganisms.
It is active against Gram-positive bacteria: Staphyloccocus aureus, Streptococcus spp, Bacillus anthracis; Gram-negative bacteria: Neisseria meningitidis, Bartonella bacilliformis, Vibrio cholerae, Esherichia coli, Klebsiella spp., Shigella spp., Acinetobacter spp., Haemophilus spp.; anaerobic bacteria: Clostridium spp., Bacteroides spp.
Minotsiklin is also active against Mycobacterium spp. (including Mycobacterium leprae), Chlamydia spp., Ureaplasma urealyticum, Treponema pallidum.
Indications
Acne, nocardiasis, leprosy (as part of combination therapy); infectious and inflammatory diseases caused by pathogens sensitive to minocycline (including pneumonia, bronchitis, pleural empyema, angina, cholecystitis, pyelonephritis, intestinal infections, endocarditis, endometritis, prostatitis, syphilis, gonorrhea, brucellosis, rickettsiosis, purulent soft tissue infections, osteomyelitis, trachoma).
Contraindications
Sensitivity to tetracyclines.
Usage during pregnancy and lactation
Minocycline penetrates the placental barrier and is excreted with breast milk.
It is not used during the second half of pregnancy and lactation period because minocycline causes discoloration of teeth, enamel hypoplasia and fetal and child skeletal bones growth disorders.
Administration in liver dysfunction
It is contraindicated in patients with liver dysfunction.
Dosage and administration
- When administered orally, the daily dose for adults is 100-200 mg.
- For children over 8 years of age the dose is 4 mg/kg and then 2 mg/kg every 12 hours.
