Description
Metrovagin Pharmacodynamics
Antiprotozoal and antibacterial drug, a derivative of 5-nitroimidazole. Mechanism of action consists in biochemical reduction of the 5-nitrogroup of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitrogroup of metronidazole interacts with the DNA of the microbial cell, inhibiting the synthesis of their nucleic acids, which leads to the death of the bacteria.
It is active against:
– protozoa – Trichomonas vaginalis, Entamoeba histolytica, Lamblia intestinalis, Balantidium coli;
– Gram-negative anaerobes – Bacteroides spp. (including B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Fusobacterium spp;
– Gram-positive anaerobic spore-forming bacilli – Eubacterium spp;
– Gram-positive anaerobic cocci – Peptococcus niger, Peptostreptococcus spp;
– microaerophiles – Gardnerella vaginalis, Helicobacter pilory.
MPC for these strains is 0.125-6.25 µg/ml.
Indications
Local treatment of trichomonas and nonspecific vaginitis.
Contraindications
Hypersensitivity to metronidazole or other nitroimidazole derivatives; blood diseases, leukopenia (including in anamnesis, decrease of leukocyte number in blood); movement disorders, organic CNS lesions (including epilepsy); liver failure (in case of high doses), pregnancy (I trimester), breast-feeding period.
If you have one of the above mentioned diseases, be sure to consult your doctor before using the drug.
Caution:
Pregnancy (II-III trimesters), history of leukopenia.
Pregnancy and lactation:
Administration of this drug is contraindicated in I trimester of pregnancy. In II and III trimester of pregnancy the drug may be administered only under strong indications and close supervision of physician.
If it is necessary to prescribe the drug during lactation, breast-feeding should be stopped because metronidazole is excreted with the breast milk. Breast-feeding can be resumed 24-48 hours after stopping the treatment.
Dosage and administration method
- Intravaginal.
- Trichomonas vaginitis: 1 suppository a day for 10 days.
- Nonspecific vaginitis: 1 suppository 2 times a day for 7 days.
- Previously releasing the suppository from the contour package with scissors (cut the film on the contour of the suppository), introduce it deep into the vagina.
