Description
Meloxicam Canon Pharmacodynamics
Meloxicam Canon Gel contains meloxicam – a non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic effects.
The mechanism of action is associated with inhibition of prostaglandin synthesis as a result of selective inhibition of enzymatic activity of cyclooxygenase-2 (COX-2), which is involved in the biosynthesis of prostaglandins in the inflammatory area.
To a lesser extent, meloxicam acts on cyclooxygenase-1 (COX-1), involved in the synthesis of prostaglandins that protect the mucosa of the gastrointestinal tract (GIT) and are involved in the regulation of blood flow in the kidneys.
Meloxicam is a “chondroneutral” drug, has no adverse effect on cartilage tissue, does not affect the synthesis of proteoglycan by chondrocytes of articular cartilage.
When applied topically, the drug reduces or eliminates pain in the area of the gel application, including joint pain at rest and on the move. Helps to increase the volume of movement.
Indications
Symptomatic treatment of osteoarthritis accompanied by pain syndrome;
Used for symptomatic therapy, reduction of pain and inflammation; has no effect on disease progression
Contraindications
– Hypersensitivity to meloxicam and other components of the drug (including other NSAIDs);
– Complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis and intolerance to acetylsalicylic acid or other NSAIDs (including history);
– Skin integrity disorders in the area of the intended application;
– Children under 18 years of age (effectiveness and safety has not been established);
– pregnancy.
Dosage and administration
- Outwardly. Do not use internally!
- A 4 cm long strip of gel (2 g) is applied 2 times a day in a thin layer to clean dry skin over the lesion and gently rubbing for 2-3 minutes.
- Duration of therapy course is determined individually, may vary depending on the lesion and the therapeutic effect noted and is no more than 4 weeks.
