Description
Meldonium Pharmacodynamics
Meldonium is a structural analogue of the carnitine precursor, gamma-butyrobetaine (GBB), a substance found in every cell of the human body.
Under conditions of increased stress, meldonium restores the balance between cellular oxygen supply and demand, eliminates the accumulation of toxic products of metabolism in cells, protecting them from damage, and has a tonic effect. Its use increases the body’s resistance to stress and its ability to quickly restore energy reserves.
The drug has a stimulating effect on the central nervous system (CNS), increasing motor activity and physical endurance. Thanks to these properties, Meldonium is used for increasing physical and mental performance.
Indications
Reduced performance, mental and physical overload.
Contraindications
Hypersensitivity to meldonium or any other component of the drug. Increased intracranial pressure (with venous outflow disorders, intracranial tumors), Pregnancy and breast-feeding.
Age under 18 years (safety has not been confirmed).
Caution
Dosages 250 mg, 500 mg.
In liver and/or kidney disease.
Administration during pregnancy and breastfeeding.
Dosages 250 mg, 500 mg
The safety of application in pregnant women has not been investigated; therefore, to avoid possible adverse effects on fetus, it is contraindicated for pregnant women. Excretion into the milk and the effect on the health of the baby have not been studied, so stop breast-feeding if necessary.
Before using Meldonium, if you are pregnant or think that you may be pregnant, or if you are planning to become pregnant, consult your physician.
Dosage and administration
- Orally, before meals.
- Due to possible development of excitatory effect, it is recommended to use in the first half of the day and not later than 17.00 when taken several times a day.
1.Coronary heart disease (angina pectoris, myocardial infarction), chronic heart failure and dyshormonal cardiomyopathy - As part of complex therapy, 500-1000 mg per day orally, using the whole dose at once or dividing it into 2 times. Course of treatment: 4-6 weeks.
- Dyshormonal cardiomyopathy – in the complex therapy of 500 mg orally per day. Course of treatment: 12 days.
2.Subacute and chronic cerebrovascular disorders (after a stroke, cerebrovascular failure). - As part of complex therapy after completion of injection therapy with Meldonium, the drug continues to be taken orally at 500-1000 mg per day, using the entire dose at once or dividing it into 2 times. Course of treatment: 4-6 weeks.
- In chronic disorders – as part of the complex therapy of 500 mg orally per day. Total course of treatment: 4-6 weeks.
- Repeated courses (usually 2-3 times a year) are possible after consultation with the doctor.
3.Reduced performance, mental and physical overload. - Adults – inside 500 mg two times a day. The course of treatment: 10-14 days.
- If necessary, treatment should be repeated in 2-3 weeks.
4.withdrawal syndrome in chronic alcoholism (in combination with specific therapy) - By mouth 500 mg 4 times a day. Course of treatment: 7-10 days.
