Melatonin 3 mg – [30 tablets]

Description

Melatonin-SZ Pharmacodynamics
A synthetic analog of the pineal body hormone (epiphysis); has an adaptogenic, sedative, and hypnotic effect. Normalizes circadian rhythms. Increases the concentration of gamma-aminobutyric acid (GABA) and serotonin in the midbrain and hypothalamus, changes the activity of pyridoxal kinase, involved in the synthesis of GABA, dopamine and serotonin. Regulates the sleep-wake cycle, daily changes in locomotor activity and body temperature, has a positive effect on the brain’s intellectual and mnemastic functions, and on the emotional-personal sphere. Contributes to the organization of the biological rhythm and normalization of night sleep. Improves the quality of sleep, accelerates falling asleep, regulates neuroendocrine functions. Adapts the organism of weather-sensitive people to changes in weather conditions.

Indications
In disorders of sleep, including those caused by a violation of the rhythm of “sleep-wake”, such as desynchronosis (rapid change of time zones).

Contraindications .
Hypersensitivity to the components of the drug, autoimmune diseases, liver failure, severe renal failure, pregnancy, breast-feeding, children under 18 years of age.
18 years old.
Caution
Medication Melatonin-SZ should be used with caution in patients with various degrees of renal failure.
Administration during pregnancy and lactation
It is contraindicated in pregnant women and during breastfeeding.
Breast-feeding

Dosage and administration method.

• Inside. In case of sleep disturbance – 3 mg once a day 30-40 minutes before sleep.
• If desynchronosis as an adaptogen when changing time zones.
  1 day before a flight and during the next 2-5 days – 3 mg 30-40 minutes before sleep.
• The maximum daily dose is 6 mg.
• Elderly patients
  Melatonin metabolism decreases with age, which should be considered when choosing a dosing regimen for elderly patients.
• Taking this into account in elderly patients, it is possible to take the drug 60-90 minutes before sleep.
• Renal failure
  The effect of different degrees of renal failure on the pharmacokinetics of melatonin has not been studied, therefore melatonin should be taken with caution in these patients. In patients with severe renal insufficiency, the use of the drug is not recommended.