Description
Loratadine Pharmacodynamics
Blocker of H1-histamine receptors (long-acting). Suppresses release of histamine and leukotrein C4 from mast cells.
Prevents the development and facilitates the course of allergic reactions.
It has anti-allergic, antipruritic and antiexudative effects.
Reduces capillary permeability, prevents the development of tissue edema, relieves spasms of smooth muscles.
Anti-allergic effect develops in 30 minutes, reaches its maximum in 8-12 hours and lasts for 24 hours.
It does not affect the central nervous system and is not addictive (as it does not penetrate through the blood-brain barrier).
Indications
Allergic rhinitis (seasonal and year-round), conjunctivitis, pollinosis, urticaria (including chronic idiopathic), Quincke’s edema, allergic pruritic dermatoses, pseudo-allergic reactions caused by histamine release, allergic reactions to insect bites.
Contraindications
Hypersensitivity to the components of the drug, pregnancy, lactation, children under 2 years of age.
With caution:
Liver failure.
Dosage and administration.
- Inside, regardless of the time of the meal.
- It is recommended to adults, including elderly ones and adolescents over 12 years old to take the drug Loratadine in dose of 10 mg (2 scoops (10 ml) of solution) once a day.
- When using the drug in elderly patients and in patients with chronic renal failure, no dose adjustment is required.
- For children aged 2 to 12 years, the dose of the drug Loratadine is recommended to be prescribed depending on body weight:
30 kg or less – 5 mg (1 scoop (5 ml) of solution) once a day;
over 30 kg – 10 mg (2 scoops (10 ml) of the solution) once a day. - In adults and children with severe liver function disorders, the initial dose should be:
if body weight is 30 kg or less – 5 mg (1 scoop (5 ml) of solution) once a day;
for body weight over 30 kg – 10 mg (2 scoops (10 ml) of the solution) every other day.
