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Ketoprofen (Ketoprovel) 100 mg – [30 tablets]


Non-steroidal anti-inflammatory drug (nsaid)

SKU: 61733 Category:


Ketoprovel Pharmacodynamics
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID). It has anti-inflammatory, analgesic and antipyretic effects. Ketoprofen blocks the action of the enzyme cyclooxygenase 1 and 2 (COX-1 and COX-2) and, partially, lipoxygenase, which leads to suppression of prostaglandin synthesis (including in the central nervous system (CNS), most likely in the hypothalamus). Stabilizes in vitro and in vivo liposomal membranes and inhibits bradykinin and leukotrienes synthesis at high in vitro concentrations.
Ketoprofen has no negative effect on articular cartilage.

Symptomatic therapy for painful and inflammatory processes of different origin, including inflammatory and degenerative diseases of the musculoskeletal system:
– rheumatoid arthritis;
– Seronegative arthritis: ankylosing spondylitis (Behterev’s disease), psoriatic arthritis, reactive arthritis (Reiter’s syndrome);
– Gout, pseudopodagra;
– osteoarthritis;
– tendinitis, bursitis, myalgia, neuralgia, radiculitis;
– Pain syndrome, including mild, moderate, and severe;
– headache;
– toothache;
– Post-traumatic and post-operative pain syndrome;
– pain syndrome in cancer;
– algodysmenorrhea.

– Hypersensitivity to ketoprofen or other components of the drug, as well as salicylates or other NSAIDs;
– complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and sinuses and intolerance to acetylsalicylic acid or other NSAIDs (including history);
– gastric or duodenal ulcer in the acute stage;
– Ulcerative colitis: Crohn’s disease;
– Hemophilia and other blood clotting disorders;
– severe hepatic insufficiency;
– severe renal insufficiency (creatinine clearance less than 30 ml/min);
– decompensated heart failure;
– postoperative period after aortocoronary bypass surgery;
– gastrointestinal, cerebrovascular, or other bleeding (or suspected
– advanced kidney disease, diverticulitis, active liver disease, inflammatory bowel disease, confirmed hyperkalemia;
– chronic dyspepsia;
– Children under 15 years of age;
– Pregnancy over 20 weeks;
– Breast-feeding period.

Dosage and administration

  • Orally.
  • The drug should be swallowed in whole with or after meals, followed by water or milk (amount of liquid should be not less than 100 ml).
  • Usually, 1 tablet 2 times a day is prescribed.
  • Oral ketoprofen preparations can be combined with the use of rectal suppositories, for example, a patient can take 1 tablet (100 mg) of ketoprofen in the morning and inject 1 suppository (100 mg) rectally in the evening.
  • The maximum dose of ketoprofen is 200 mg/day.
  • It is not recommended to exceed the maximum daily dose of the drug.
  • In order to reduce the risk of gastrointestinal (GI) adverse events, patients with risk factors are recommended to take proton pump inhibitors simultaneously.