Description
Ketoprofen-Organica Pharmacodynamics
Non-steroidal anti-inflammatory drug. It has anti-inflammatory, analgesic and antipyretic effects associated with inhibition of cyclooxygenase 1 and cyclooxygenase 2 activity, which regulate Pg synthesis. By acting on cyclooxygenase and lipooxygenase link of arachidonic acid metabolism, it inhibits synthesis of prostaglandins, leukotrienes and thromboxanes. It has central and peripheral analgesic effect, anti-bradykinin activity, stabilizes lysosomal membranes, causes significant inhibition of neutrophil activity in rheumatoid arthritis patients. It has no catabolic effect on articular cartilage.
Anti-inflammatory effect occurs by the end of the first week of use.
Indications
Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid, psoriatic arthritis, Bechterew’s disease (ankylosing spondylitis), gouty arthritis (in an acute attack of gout preferable fast-acting forms), osteoarthritis;
pain syndrome: myalgia, ossalgia, neuralgia, tendinitis, arthralgia, bursitis, radiculitis, adnexitis, otitis, headache and toothache, with cancer, post-traumatic and postoperative pain syndrome, accompanied by inflammation;
algodysmenorrhea (as an analgesic and tonic).
Contraindications
Hypersensitivity to ketoprofen (including other NSAIDs);
Gastric and duodenal ulcer (exacerbation);
Crohn’s disease;
diverticulitis;
Blood clotting disorders, including hemophilia;
Chronic renal insufficiency;
Pregnancy (III trimester);
Childhood (under 15 years).
Hypersensitivity to other components of the drug and salicylates;
severe heart failure;
treatment of postoperative pain during coronary artery bypass surgery;
chronic dyspepsia;
active peptic gastric ulcer or ulceration/perforation;
gastrointestinal, cerebrovascular, or other bleeding; patients prone to hemorrhage;
Severe hepatic or renal dysfunction;
bronchial asthma;
History of rhinitis or urticaria caused by taking acetylsalicylic acid or other NSAIDs;
lactation period.
aspirin asthma;
peptic ulcer;
ulcerative colitis (exacerbation).
Dosage and administration
- The preparation is prescribed 4 capsules to adults and adolescents (15-18 years old) per day, which can be divided into 3 doses (depending on the severity of the pain syndrome), but not more than 2 caps. once. The maximum daily dose should not exceed 200 mg.
