Description
Kagocel Pharmacokinetics
In 24 hours after injection, cagocel accumulates in the body, mainly in liver, and to a lesser degree in lungs, thymus, spleen, kidneys, lymph nodes. Low concentrations are noted in adipose tissue, heart, muscles, testes, brain, blood plasma. Low content of cagocel in brain is explained by high molecular weight of the drug, which complicates its penetration through the blood-brain barrier. In blood plasma the drug is mainly in bound form.
With daily repeated administration of cagocel, the volume of distribution varies widely in all organs studied. Accumulation of the drug in spleen and lymph nodes is especially pronounced. When administered orally, about 20% of the administered drug dose enters the general bloodstream. Absorbed drug circulates in blood mainly in macromolecule-bound form: with lipids – 47%, with proteins – 37%. The unbound part of the drug is about 16%.
Excretion: the drug is excreted from the body mainly through intestine: 88% of the administered dose is excreted in 7 days after injection, including 90% through the intestine and 10% through kidneys. In exhaled air the drug is not detected.
Indications
Kagocel is used in adults and children over 3 years old as a prophylactic and therapeutic agent against influenza and other acute respiratory viral infections (ARI), as well as a therapeutic agent against herpes in adults
Contraindications .
– Pregnancy and breast-feeding;
– Age under 3 years;
– Hypersensitivity to the drug components;
– Lactase deficiency, lactose intolerance, glucose-galactose malabsorption.
With caution:
Pregnancy and lactation:
Due to the lack of necessary clinical data, the drug is contraindicated in pregnancy and during breastfeeding.
Dosage and administration method
- Inside, regardless of meals.
- For the treatment of flu and acute respiratory infections in adults prescribed the first two days – two tablets three times a day, the next two days – one tablet three times a day. Total for the course – 18 tablets, the duration of the course – 4 days.
- The prophylaxis of flu and acute respiratory viral infections in adults is made in 7-day cycles: two days – 2 tablets 1 time per day, a 5-day break, then the cycle is repeated. The duration of the prophylactic course is from one week to several months.
- For the treatment of herpes in adults we prescribe 2 tablets 3 times a day for 5 days. A total of 30 tablets for the course, the duration of the course is 5 days.
- For the treatment of flu and acute respiratory viral infections in children aged 3 to 6 years are prescribed for the first two days – 1 tablet 2 times a day, the next two days – 1 tablet once a day. Total for the course – 6 tablets, the duration of the course – 4 days.
- For the treatment of flu and acute respiratory viral infections in children aged 6 years are prescribed for the first two days – one tablet 3 times a day, the next two days – one tablet two times a day. Total for the course – 10 tablets, the duration of the course – 4 days.
- The prophylaxis of flu and acute respiratory viral infections in children at the age from 3 years is carried out in 7-day cycles: two days – 1 tablet once a day, 5 days break, then the cycle is repeated. The duration of the prophylactic course is from one week to several months.
- If after treatment no improvement occurs or symptoms worsen, or new symptoms appear, you should consult a doctor.
- Use the drug only according to the indications, the method of administration and in the doses specified in the instructions.
