Description
Hydrocortisone Akos Pharmacodynamics
Hydrocortisone – a natural glucocorticosteroid. It has anti-inflammatory, anti-allergic effect. It reduces inflammatory cell infiltrates, decreases migration of leukocytes and lymphocytes into the inflamed area. Stabilizes cellular and subcellular, including lysosomal membranes and membranes of mast cells. Reduces immunoglobulin binding to cell surface receptors and inhibits the synthesis or release of cytokines (interleukins and interferon) from lymphocytes and macrophages. Reduces the release of arachidonic acid from phospholipids and the synthesis of its metabolites (prostaglandins, leukotrienes, thromboxane). Reduces exudative reaction, helps to reduce capillary permeability. It reduces the severity of early immunological response. It has catabolic action and inhibits the development of connective tissue and scarring.
Indications
– Allergic eye diseases (eyelid dermatitis, blepharitis, conjunctivitis and keratoconjunctivitis);
– Inflammatory diseases of the anterior eye in the absence of corneal epithelial integrity disorders (blepharitis, conjunctivitis and keratoconjunctivitis);
– Thermal and chemical burns (after complete epithelialization of corneal defects).
Contraindications
– Hypersensitivity to the components of the drug;
– Purulent, viral, tuberculous, fungal eye diseases;
– glaucoma;
– trachoma;
– Vaccination period;
– disorders of the integrity of the eye membranes;
– under 18 years of age.
Use in pregnancy and during breastfeeding
Studies of safety and efficacy of hydrocortisone in pregnant and lactating women have not been conducted. There are no definitive data on the penetration into breast milk of glucocorticosteroids when topically applied. However, the risk cannot be completely excluded. The use of hydrocortisone in pregnant and lactating women is allowed only when prescribed by the attending physician when the expected therapeutic effect for the mother exceeds the potential risk to the fetus or child.
The duration of use should not exceed 7-10 days.
Directions for use and dosages
- Topically.
- 1 cm of the eye ointment is injected into the conjunctival sac 2-3 times a day.
- The course of treatment is 1-2 weeks. The course of treatment may be prolonged upon recommendation of a doctor.
