Heparin sodium, lidocaine, prednisolone (Hepazolon) rectal – [10 suppositories]

Description

Hepazolone Pharmacodynamics
Pharmacological action is determined by the properties of the components included in the preparation.
Heparin prevents thrombus formation, prevents blood coagulation in hemorrhoidal nodes, has an anti-edema effect, promotes regeneration of connective tissue, accelerates healing and reduces the number of relapses of the disease. Heparin inhibits reactions that cause blood coagulation and form fibrin clots. Heparin in this dosage in combination with plasma antithrombin III inhibits thrombosis by deactivating factor Xa and also by inhibiting the conversion of prothrombin to thrombin. Heparin prevents the formation of stable fibrin thrombus by inhibiting the activation of fibrin-stabilizing factor. Heparin also shows anti-inflammatory effect, affecting vascular endothelium, prevents edema.
Prednisolone belongs to the group of synthetic glucocorticosteroids of medium duration of action, it reduces formation, release and activity of inflammatory mediators (histamine, kinin, prostaglandin, lysosomal enzymes). Inhibits cell migration to the site of inflammation; reduces vasodilation and increased vascular permeability in the inflammation focus. Reduces exudation due to vasoconstrictor action. Suppresses the action of macrophages, target cells, cytokines, which are involved in the development of allergic reactions. Prevents the access of sensitized T-lymphocytes and macrophages to the target cells. It has anti-inflammatory, anti-exudative and anti-allergic effects, reduces inflammation and associated subjective sensations (itching, burning, pain, moist feeling due to eczematous changes) in the anorectal area.
Lidocaine has a local anesthetic effect, which is due to blockade of voltage-dependent sodium channels, which prevents the generation of impulses in the endings of sensitive nerves and conduct of pain impulses along the nerve fibers. The combined action of the components of the drug achieves the best effect.

Indications
External and internal hemorrhoids, including acute, thrombophlebitis hemorrhoid veins perianal area, fistulas, eczema, itching in the anus caused by inflammation, anal fissures, preparation for surgical intervention in the anorectal zone, in the treatment of thrombosed and operated hemorrhoids.

Contraindications
– Hypersensitivity to the components of the drug.
– Viral, fungal, tuberculosis and other infectious processes of the anorectal area, coagulation disorders with predisposition to bleeding.
– Pregnancy and lactation period.
– Childhood under 12 years of age.

Dosage and administration

• When internal hemorrhoids suppository injected into the rectal cavity 1-2 times a day.
• When external hemorrhoids suppository introduced into the anus incompletely – its base should be palpable to the outside. Hold the anus with a gauze napkin until the suppository melts (2-3 minutes), otherwise the suppository “fell” into the rectum, not having a therapeutic effect.
• The course of treatment – 7 days.
• The course may be prolonged up to 14 days, as recommended by the doctor.