Furazidin (Furagin-Aktifur) 50 mg – [30 capsules]

Antimicrobial agent, nitrofuran derivative. Effective against Gram-positive cocci (Staphylococcus spp., Streptococcus spp.), Gram-negative bacilli (Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp.). Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp., most strains of Proteus spp., Serratia spp. are resistant.

Furazidine is reduced by bacterial flavoproteins to active compounds that inactivate or damage proteins of bacterial ribosomes and other macromolecules. As a result, aerobic respiration and processes of protein, cell wall, DNA, and RNA synthesis are disrupted. Multiple mechanism of action explains weak acquired resistance of microorganisms to nitrofurans.

Depending on the concentration, it has a bactericidal or bacteriostatic effect. Against most bacteria, the bacteriostatic concentration is 10 to 20 µg/ml. The bactericidal concentration is about 2 times higher. As a result of the action of nitrofurans, microorganisms release fewer toxins, so that improvement of the general condition of the patient is possible even before a pronounced suppression of microflora growth.

Infectious and inflammatory diseases: of the urinary tract (cystitis, urethritis, pyelonephritis), infections of the female reproductive organs, prevention of infections during urologic surgery, cystoscopy, catheterization.

Contraindications .

– Hypersensitivity to Furazidin, or other components of the drug;

– Hypersensitivity to nitrofuran derivatives;

– impaired renal function;

– impaired liver function;

– Lactase, sucrose/isomaltose deficiency, lactose intolerance, fructose, glucose-galactose malabsorption;

– pregnancy;

– lactation;

– children under 18 years of age.

Furazidine is not recommended for urosepsis and renal parenchyma infections.

Caution

In anemia, lung diseases (especially in patients older than 65 years), nervous system disorders, diabetes, porphyria, deficiency of glucose-6-phosphate dehydrogenase, B vitamins and folic acid.

Administration during pregnancy and lactation

It is contraindicated in pregnancy and during breast-feeding.