Description
Ethoxidol Pharmacodynamics
Ethoxidol is an inhibitor of free radical processes, has membranoprotective, antihypoxic, nootropic, anticonvulsant, anxiolytic effect, increases the body’s resistance to stress. Etoxidol® has anti-ischemic properties, improves blood flow in ischemic area, limits the area of ischemic injury, shows hypolipidemic action, reduces the content of total cholesterol and low-density lipoproteins.
The drug increases the body’s resistance to various damaging factors, to oxygen-dependent pathological conditions (shock, hypoxia and ischemia,
cerebral circulation disorders, intoxication with alcohol and antipsychotic drugs (neuroleptics)).
The drug improves cerebral metabolism and blood supply to the brain, improves microcirculation and blood rheological properties, reduces platelet aggregation. It stabilizes membrane structures of blood cells (erythrocytes and platelets) during hemolysis.
The mechanism of action of the drug is due to its antioxidant, antihypoxant and membrane-protective effects. It inhibits lipid peroxidation, increases superoxidase activity, increases lipid-protein ratio, reduces membrane viscosity and increases its fluidity. Modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which increases their ability to bind to ligands, helps maintain the structural and functional organization of biomembranes, transport neurotransmitters and improve synaptic transmission.
Indications
- Coronary heart disease (as part of complex therapy);
- Complex therapy of ischemic stroke;
- discirculatory encephalopathy;
- Mild to moderate cognitive disorders.
Contraindications
- Hypersensitivity to the components of the drug, lactose intolerance, lactase deficiency, glucose-galactose malabsorption.
- Acute hepatic and/or renal failure, pregnancy, lactation, age less than 18 years.
- (effectiveness and safety have not been established).
- Application during pregnancy
- Etoxidol® is contraindicated in pregnancy and during breast feeding period, because strictly controlled clinical trials of safety of drug administration during pregnancy and breast feeding period have not been carried out.
Dosage and administration
- Ethoxidol tablets are administered orally. Tablets are chewed and swallowed with water.
- For complex therapy of ischemic heart disease and therapy of ischemic stroke, 100 mg (1 tablet) 3 times daily, gradually increasing dose to obtain therapeutic effect. The maximum single dose is 200 mg; the daily dose is 800 mg. The course – at least two months, repeated courses – on the advice of a doctor.
- The duration of treatment and selection of an individual dose depends on the severity of the patient’s condition and the effectiveness of treatment.
- In complex therapy of mild and moderate cognitive disorders, the drug is prescribed without limiting the duration of treatment in a dose of 100 mg 3-4 times a day.