Description
Esslial Forte (phospholipides) 300 mg Pharmacodynamics
Essential phospholipids are basic elements of cell membrane structure and liver cell organelles. In liver diseases there is always damage of liver cell envelopes and their organelles that leads to disturbances in activity of associated enzymes and receptor systems, worsens functional activity of liver cells and decreases ability to regenerate.
Phospholipids, included in the drug Esslial Forte, correspond to the chemical structure of endogenous phospholipids, but exceed endogenous phospholipids in activity due to their higher content of polyunsaturated (essential) fatty acids. The incorporation of these high-energy molecules into the damaged parts of hepatocyte cell membranes restores the integrity of hepatic cells and promotes their regeneration. Cis-double bonds of their polyunsaturated fatty acids prevent parallel arrangement of hydrocarbon chains in phospholipids of cell membranes, the density of phospholipid structure of hepatocyte cell membranes decreases, which causes increase of their fluidity and elasticity, improves metabolism. Formed functional blocks increase activity of enzymes fixed on membranes and contribute to normal physiological course of the most important metabolic processes.
Phospholipids contained in Esslial forte regulate lipoprotein metabolism by transporting neutral fats and cholesterol to the oxidation sites, mainly by increasing the ability of high-density lipoproteins to bind to cholesterol
Thus, there is a normalizing effect on lipid and protein metabolism; on detoxification function of the liver and phospholipid-dependent enzyme systems; that eventually prevents formation of connective tissue in the liver and promotes natural regeneration of liver cells.
When phospholipids are excreted into bile, the lithogenic index decreases and bile stabilizes.
Indications for using Phospholipides (Esslial Forte) 300 mg
Chronic hepatitis, cirrhosis, fatty liver dystrophy of various etiologies, toxic liver injury, alcoholic hepatitis, liver dysfunction in other somatic diseases. Toxicosis of pregnancy, prevention of recurrence of gallstones, psoriasis (as an adjuvant therapy), radiation syndrome
Contraindications .
Hypersensitivity to phosphatidylcholine or other excipients of the drug. Hypersensitivity to soybeans. Children under 12 years of age (insufficient evidence).
Dosage and administration
- Orally. The capsules should be taken in whole with enough water (about 1 cup).
- For adolescents older than 12 years of age and over 43 kg, as well as for adults – 2 capsules 3 times a day with meals.
- As a rule, the duration of use is not limited.