Description
Erythromycin is an antibiotic that is used to treat a wide range of bacterial infections. It is effective in treating infections caused by a variety of bacteria, such as streptococci, staphylococci, and certain anaerobic bacteria.
Erythromycin ointment Pharmacodynamics
Erythromycin ointment has a bacteriostatic action. However, in high doses against sensitive microorganisms it has a bactericidal effect. Erythromycin reversibly binds to bacterial ribosomes, thus inhibiting protein synthesis.
It is active against Gram-positive bacteria: Staphylococcus spp. (penicillinase-producing and non-producing strains), Streptococcus spp. (including Streptococcus pneumoniae); Gram-negative bacteria: Neisseria gonorrhoeae, Haemophilus influenzae, Bordetella pertussis, Brucella spp, Legionella spp., Bacillus anthracis, Corynebacterium diphtheriae; anaerobic bacteria: Clostridium spp.
Erythromycin is also active against Mycoplasma spp., Chlamydia spp., Spirochaetaceae, Rickettsia spp.
Gram-negative bacilli, including Escherichia coli, Pseudomonas aeruginosa, Shigella spp.
Indications
Infectious-inflammatory diseases caused by microorganisms sensitive to erythromycin, including diphtheria, whooping cough, trachoma, brucellosis, legionnaires’ disease, angina, scarlet fever, otitis media, sinusitis, cholecystitis, pneumonia, gonorrhea, syphilis. Treatment of infectious and inflammatory diseases caused by pathogens (in particular, staphylococci) resistant to penicillin, tetracyclines, chloramphenicol, streptomycin.
For external use: juvenile acne.
For local use: infectious-inflammatory eye diseases.
Contraindications
Jaundice in anamnesis, marked liver dysfunction, hypersensitivity to macrolides.
Dosage and administration method
- It is established individually depending on localization and severity of course of infection, sensitivity of causative agent. It is used in a daily dose of 1-4 g in adults. Children under 3 months of age – 20-40 mg/kg/year; 4 months to 18 years of age – 30-50 mg/kg/year The course of treatment – 5-14 days, after symptoms disappearance, treatment is continued for 2 more days. Taken 1 hour before a meal or 2-3 hours after a meal.
- Solution for external use to lubricate the affected areas of skin.
- The ointment is applied to the affected area, and in diseases of the eyes put behind the lower eyelid. Dose, frequency and duration of application are determined individually.