Description
Doxycycline Unidox Solutab Tablets – Pharmacodynamics
Doxycycline Unidox Solutab tablets are a broad-spectrum antibiotic belonging to the tetracycline group. It exhibits bacteriostatic properties and inhibits protein synthesis in microbial cells by interacting with the 30S ribosome subunit. It effectively targets various Gram-positive and Gram-negative microorganisms, including Streptococcus spp., Staphylococcus spp., Neisseria spp., Chlamydia spp., Mycoplasma spp., and more.
Indications
Doxycycline Unidox Solutab tablets are indicated for the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug. This includes respiratory tract infections, ENT organ infections, urogenital system infections, gastrointestinal tract infections, skin and soft tissue infections, and more.
Contraindications
Doxycycline Unidox Solutab tablets should not be used in individuals with hypersensitivity to doxycycline or other tetracyclines, during pregnancy and breastfeeding, in children under 8 years of age, individuals with severe liver or kidney dysfunction, porphyria, lactase deficiency, lactose intolerance, or glucose-galactose malabsorption.
Administration during Pregnancy and Lactation
Doxycycline should be avoided during pregnancy and breastfeeding due to potential adverse effects on the fetus and infant. However, it may be considered in cases of severe infections where no alternative treatments are available. Women of childbearing age should have pregnancy ruled out before receiving doxycycline.
How to Use and Dosages
– Take Doxycycline Unidox Solutab tablets by dissolving them in a small amount of water.
– The duration of treatment is typically 5-10 days.
– Preferably taken with meals.
– Dosage varies based on age, weight, and severity of infection.
Peculiarities of Dosing in Some Diseases
– In cases of infection caused by Streptococcus pyogenes, treatment with Doxycycline Unidox Solutab tablets should continue for at least 10 days.
– For uncomplicated gonorrhea (except anorectal infections in men), the recommended dosage is 100 mg twice a day until complete cure (average duration: 7 days), or 600 mg in divided doses on a single day.
– Primary syphilis requires 100 mg twice a day for 14 days, while secondary syphilis necessitates 100 mg twice a day for 28 days.
– Uncomplicated urogenital infections caused by Chlamydia trachomatis or Ureaplasma urealiticum should be treated with 100 mg twice a day for 7 days.
– For acne treatment, the recommended dosage is 100 mg per day for 6-12 weeks.
– Malaria prophylaxis involves taking 100 mg once a day 1-2 days before the trip, during the trip, and for 4 weeks after return. Children over 8 years old should take 2 mg/kg once a day.
– Traveler’s diarrhea prophylaxis includes 200 mg on the first day of the trip, followed by 100 mg once a day during the stay (not exceeding 3 weeks).
– Leptospirosis treatment requires 100 mg orally twice a day for 7 days. Leptospirosis prophylaxis involves taking 200 mg once a week during exposure and 200 mg at the end of the trip.
– To prevent infections during a medical abortion, take 100 mg 1 hour before and 200 mg after the procedure.
– Maximum daily doses vary based on age, weight, and condition, and may need adjustment for individuals with renal or hepatic impairment.
[DOXYCYCLINE (UNIDOX SOLUTAB®) AND/OR JOSAMYCIN (WILPRAFEN®) IN TREATMENT OF PATIENTS WITH PROSTATITIS IN REAL CLINICAL PRACTICE. RESULTS OF THE TAURUS OBSERVATIONAL PROGRAM]
