Description
Diosmin + hesperidin Pharmacodynamics
The combination of hesperidin and diosmin has venotonic and angioprotective properties.
It reduces venous distensibility and venous stasis, decreases capillary permeability and increases their resistance, improves indices of venous hemodynamics. It affects the following venous plethysmographic parameters: venous capacity, venous distensibility, time of venous emptying. The optimal effect is achieved when taking 1000 mg of the drug.
The combination of hesperidin+diosmin increases venous tone by reducing the time of venous emptying. In patients with signs of severe microcirculatory disorders, there is an increase in capillary resistance.
The combination hesperidin+diosmin is effective in the treatment of chronic diseases of lower limb veins, as well as in the treatment of hemorrhoids.
Indications
Therapy of symptoms of chronic venous diseases (elimination and relief of symptoms):
– Therapy of symptoms of venous-lymphatic insufficiency (pain, cramps of the lower extremities, a feeling of heaviness and tenseness in the legs, “tiredness” of the legs);
– Therapy of manifestations of venous and lymphatic insufficiency (edema of the lower extremities, trophic changes in the skin and subcutaneous tissue, venous trophic ulcers).
Symptomatic therapy for acute and chronic hemorrhoids.
Contraindications
Hypersensitivity to the active or excipients that make up the drug;
Breast-feeding period.
Application during pregnancy and breast-feeding.
Pregnancy
Experiments on animals have not revealed teratogenic effects. Until now, there have been no reports of undesirable effects when using the combination hesperidin + diosmin by pregnant women.
Breast-feeding period
Due to lack of data concerning excretion of the drug with the breast milk, its administration is not recommended during breastfeeding.
Effect on fertility
Studies of reproductive toxicity showed no effect on reproductive function in rats of either sex.
Dosage and administration method
- Oral.
- The recommended dosage for venous-lymphatic insufficiency is 2 tablets daily (in one or two doses): in the morning, during the day and/or in the evening, with meals. Tablets should be swallowed whole with water.
- The duration of treatment may be several months (up to 12 months). If the recurrence of symptoms, upon the recommendation of the doctor, the treatment course may be repeated.
- The recommended dose for acute hemorrhoids – 6 tablets per day: 3 tablets in the morning and 3 tablets in the evening for 4 days; then 4 tablets a day for 2 tablets in the morning and 2 tablets in the evening for the next 3 days.
- The recommended dose for chronic hemorrhoids is 2 tablets per day with meals.
