Description
Venolek Pharmacodynamics
The drug has phlebotonic action (decreases venous distensibility, increases venous tone (dose-dependent effect), decreases venous stasis), improves lymphatic drainage (increases tone and frequency of contraction of lymphatic capillaries, increases their functional density, decreases lymphatic pressure), it improves microcirculation (increases capillary resistance (dose-dependent effect), decreases their permeability), reduces leukocyte adhesion to the venous wall and their migration to paravenous tissue, improves oxygen diffusion and perfusion in the skin tissue, has anti-inflammatory effect. It enhances vasoconstrictor effect of adrenaline, noradrenaline, blocks production of free radicals, synthesis of prostaglandins and thromboxane.
Indications
As part of the complex therapy:
– To eliminate the symptoms of venous insufficiency of the lower limbs, such as a feeling of heaviness and pain in the legs;
– To eliminate the symptoms of acute hemorrhoids.
Contraindications
Hypersensitivity, pregnancy (first trimester) (experience of use limited), lactation, children under 18 years of age.
Pregnancy and breast-feeding period
It is possible to use the drug during pregnancy. Experimental and clinical studies have shown no embryotoxic, mutagenic and teratogenic effects. Up to date there have been no reports of any undesirable effects during drug administration in pregnant women, but it is necessary to evaluate the risk and benefit when prescribing the drug to pregnant women.
During lactation the drug administration is not recommended because of lack of data about its penetration in breast milk.
Directions for use and dosages
- Consult the physician before using the drug. The drug is intended to be taken orally. In varicose veins of the lower limbs and chronic
- Lymphovenous insufficiency is prescribed 1 tablet a day in the morning on an empty stomach. The therapy duration is usually 2 months. In severe forms of chronic lymphovenous insufficiency (edema, pain, cramps, trophic changes and ulcers) treatment may be longer. Total duration of continuous therapy shall not exceed three months.
- Treatment courses of the drug are repeated in 2-3 months. For the treatment of chronic lymphovenous insufficiency during the second and third trimesters of pregnancy 1 tablet 1 time a day is prescribed. The duration of therapy is not more than 30 days. It is necessary to stop taking the drug 2-3 weeks before delivery. If hemorrhoids are exacerbated, the drug is prescribed 2-3 tablets per day with meals for 7 days. If one or more doses of the drug are missed, it is necessary to continue using the drug as usual and in the usual dose.
