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Clindamycin, butoconazole (Clindacin B prolong) vaginal cream 2%/2% – [20 g tube]


Drug with antibacterial and antifungal action for local use in gynecology

SKU: 61753 Category:


Clindacin B Pharmacodynamics
Butoconazole is an imidazole derivative with fungicidal activity against Candida fungi, Trichophyton, Microsporum, Epidermaphyton and some Gram-positive bacteria. It is most effective against candidiasis. By blocking the formation of ergosterol from lanosterol in the cell membrane, it increases membrane permeability, which leads to lysis of the fungus cell.
Clindamycin is a bacteriostatic antibiotic of lincosamide group, it has a broad spectrum of action, binds to 50S subunit of ribosomal membrane and inhibits protein synthesis in the microbial cell. Bactericidal action is possible against a number of Gram-positive cocci.
Under in vitro conditions the following microorganisms causing bacterial vaginosis are sensitive to clindamycin: Gardnerella vaginalis, Mobiluncus spp., Mycoplasma hominis, Bacteroides spp., Peptostreptococcus spp.
A hydrophilic cream base gives the drug a gel-like consistency at 35-40°C. When used intravaginally, the cream does not melt; therefore, the active substances remain on the vaginal mucosa for 1-3 days.
There is a cross-resistance between clindamycin and lincomycin.

Bacterial vaginosis, fungal and mixed vaginitis, caused by microorganisms sensitive to the drug

Hypersensitivity to clindamycin, lincomycin, butoconazole or any drug component; inflammatory bowel diseases (Crohn’s disease, ulcerative, pseudomembranous and antibiotic-associated colitis (including anamnesis)); children under 18 years of age.

Dosage and administration

  • It is administered intravaginally with an applicator. It is used once a day, preferably before going to bed. The recommended dose is one full applicator (5 g of cream, which corresponds to 100 mg butoconazole nitrate and 100 mg clindamycin). The course of treatment is daily for 3 days.
  • Instructions for use of the applicator
    Disposable applicators included in the package are designed for precise dosing and insertion of Clindacin® B prolong cream into the vagina.
  • 1.Open the tube of cream by removing the cap. Pierce the membrane of the tube with the back of the cap. Screw the plastic applicator onto the threaded neck of the tube.
    2. Gently press the tube from the opposite end and gently squeeze the cream into the applicator. The applicator piston moves independently as it fills the desired volume. The applicator is full when the piston reaches the stop. Unscrew the applicator and close the tube with the cap.
    3. In the supine position, pull your knees up to your chest. Holding the applicator horizontally, gently insert it into the vagina as deeply as possible, taking care not to cause discomfort.
    4. Slowly pushing on the plunger until it stops, introduce the entire volume of cream into the vagina.
    5. Carefully remove the applicator from the vagina and discard it in a waste container