Description
Levomycetin-Renewal Pharmacodynamics
Bacteriostatic broad-spectrum antibiotic, disrupts protein synthesis in a microbial cell at the stage of transfer of t-RNA amino acids to ribosomes.
Effective against strains of bacteria resistant to penicillins, tetracyclines, sulfonamides.
Active against the following microorganisms: Escherichia coli, Shigella dysenteriae, Shigella flexneri, Shigella boydii, Shigella sonnei, Salmonella spp. (including Salmonella typhi, Salmonella paratyphi), Staphylococcus spp, Streptococcus spp. (including Streptococcus pneumoniae), Neisseria meningitidis, Neisseria gonorrhoeae, several strains of Proteus spp., Burkholderia pseudomallei, Rickettsia spp, Treponema spp., Leptospira spp., Chlamydia spp. (including Chlamydia trachomatis), Coxiella burnetii, Ehrlichia canis, Bacteroides fragilis, Klebsiella pneumoniae, Haemophilus influenzae.
It has no effect on acid-fast bacteria (including Mycobacterium tuberculosis), anaerobes, methicillin-resistant strains of staphylococci, Acinetobacter spp., Enterobacter spp., Serratia marcescens, indole-positive strains of Proteus spp., Pseudomonas aeruginosa, protozoa and fungi.
Resistance of microorganisms develops slowly.
Indications
Urinary and biliary tract infections caused by susceptible microorganisms.
Contraindications
– Hypersensitivity to chloramphenicol or other components of the drug;
– Inhibition of medullary hematopoiesis;
– Acute intermittent porphyria;
– glucose-6-phosphate dehydrogenase deficiency;
– hepatic and/or renal insufficiency;
– pregnancy;
– Breast-feeding period;
– children under 3 years of age and with body weight less than 20 kg.
Caution.
Patients who have previously received cytostatic drugs or radiation therapy.
Administration during pregnancy and breast-feeding.
The drug is contraindicated in pregnancy and during breast-feeding.
Dosage and administration method
- Inside (30 minutes before a meal, and with nausea and vomiting 1 hour after a meal), 3-4 times a day.
- A single dose for adults 250-500 mg, a daily dose of 2000 mg.
- In children over 3 years of age with body weight more than 20 kg a dose of 12.5 mg/kg every 6 hours or 25 mg/kg every 12 hours is administered.
- The average duration of treatment is 8-10 days.
