Description
Carbocysteine-Vertex Pharmacodynamics
Carbocysteine being a mucolytic, influences gel-phase of endobronchial secretion, breaking disulfide bridges of glycoproteins and thus reducing viscosity and increasing elasticity of secretion. Carbocysteine activates sialic transferase – an enzyme of bocalytic cells of bronchial mucosa, normalizes the quantitative ratio of acidic and neutral sialomucins, contributes to regeneration of mucosa, normalizes its structure, activates activity of ciliated epithelium, restores secretion of immunologically active IgA (specific protection), improves mucociliary clearance. The effect is dose-dependent.
Indications
-Acute and chronic bronchopulmonary diseases and diseases of ENT organs, accompanied by formation of viscous, hardly discharged sputum (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectatic disease, chronic obstructive pulmonary disease (COPD)) and mucus (inflammatory diseases of the middle ear, nose and its accessory sinuses -rinitis, otitis media, sinusitis);
-Preparation of the patient for bronchoscopy or bronchography.
Contraindications
-Hypersensitivity to carbocysteine or other drug components;
-gastric and duodenal ulcer in the acute stage;
-Chronic glomerulonephritis (acute phase);
-cystitis;
-pregnancy;
-Children under 2 years of age (for the syrup 20 mg/ml) and under 15 years of age (for the syrup 50 mg/ml);
-sugar/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
Dosage and administration
- Oral.
- Carbocysteine 20 mg / ml:
One teaspoon of syrup (5 ml) contains 100 mg carbocysteine. - Children 2-5 years of age: Take 2 times a day with one teaspoon of syrup (200 mg per day);
- Children over 5 years of age: take 3 times a day, 1 teaspoon (300 mg per day).
- Carbocysteine 50 mg/ml:
One tablespoon of syrup (15 ml) contains 750 mg carbocysteine. - Adults: Take 3 times a day in one tablespoon (2250 mg per day).
- Duration of treatment should not exceed 8 days.
- If symptoms persist for 4-5 days from the beginning of treatment, it is recommended to consult a doctor.
