Description
Caposide Pharmacodynamics
Caposide is a combination drug that has hypotensive and diuretic effects.
Captopril is an angiotensin-converting enzyme (ACE) inhibitor, reduces angiotensin II formation from angiotensin I, reduces aldosterone release, reduces total peripheral vascular resistance (TPR), blood pressure (BP), post- and preload. Dilates arteries more than veins. Enhances coronary and renal blood flow. Long-term use decreases myocardial and arterial wall resistance hypertrophy. Captopril improves blood flow to ischemic myocardium; reduces platelet aggregation.
Hydrochlorothiazide is a medium strength thiazide diuretic; it reduces Na+ reabsorption at the level of the cortical segment of the Genle loop. It does not affect acid-base status (COS). Lowers BP by changing the reactivity of the vascular wall, reducing the pressor effect of endogenous vasoconstrictors (adrenaline, noradrenaline) and increasing the depressor effect on the autonomic ganglia (to a lesser extent, by reducing circulating blood volume (CBV)). It enhances the hypotensive effect of captopril.
Indications
Arterial hypertension.
Contraindications .
Hypersensitivity to captopril, thiazide diuretics, sulfonamides (cross-allergic reactions possible); angioedema (history of ACE inhibitors); aortic stenosis, mitral stenosis; hypertrophic obstructive cardiomyopathy; bilateral renal artery stenosis, single renal artery stenosis, renal transplantation (history of) chronic heart failure; cardiogenic shock, arterial hypotension, tachycardia; severe hepatic insufficiency (precoma or coma); severe renal failure (serum creatinine > 1.8 mg/100 ml or creatinine clearance less than 20-30 ml/min, anuria); primary hyperaldosteronism; pregnancy, lactation, age less than 18 years (effectiveness and safety is not established).
Dosage and administration method
- Orally, 1 hour before a meal, 1 tablet once a day.
