Description
Miramed-Evalar Pharmacodynamics
The drug has a wide range of antimicrobial action, including hospital strains resistant to antibiotics.
The drug has a pronounced bactericidal effect against Gram-positive (Staphylococcus spp., Streptococcus spp., Streptococcus pneumoniae), Gram-negative (Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp.), aerobic and anaerobic bacteria determined as monocultures and microbial associations, including hospital strains with multiresistance to antibiotics.
It has antifungal effect on ascomycetes of the genus Aspergillus and Penicillium, yeasts (Rhodotorula rubra, Torulopsis glabrata) and yeast-like fungi (Candida albicans, Candida tropicalis, Candida krusei, Pityrosporum orbiculare (Malassezia furfur)), dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violacent, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis) as monocultures and microbial associations, including fungal microflora with resistance to chemotherapeutic drugs.
It has antiviral action, it is active against complex viruses (herpes viruses, human immunodeficiency virus).
The drug acts on sexually transmitted pathogens (Chlamydia spp., Treponema spp., Trichomonas vaginalis, Neisseria gonorrhoeae).
Effectively prevents infection of wounds and burns. Activates regeneration processes. Stimulates the protective reactions at the application site by activating the absorptive and digestive function of phagocytes, potentiates the activity of the monocytic-macrophage system. It has a pronounced hyperosmolar activity, as a result of which it stops wound and perifocal inflammation, absorbs purulent exudate, contributing to the formation of a dry crust. It does not damage granulation and viable skin cells, does not suppress marginal epithelization.
It has no local irritating effect and allergenic properties.
Indications
Otorhinolaryngology: complex treatment of acute and chronic external otitis media, maxillitis, tonsillitis, pharyngitis, laryngitis.
Dentistry: treatment and prevention of infectious and inflammatory diseases of the mouth: stomatitis, gingivitis, periodontitis.
Hygiene treatment of removable dentures.
Surgery, traumatology: prevention of suppuration and treatment of purulent wounds. Treatment of purulent inflammatory processes of the musculoskeletal system.
Obstetrics-gynecology: prevention and treatment of suppuration of postpartum trauma, perineal and vaginal wounds, postpartum infections, inflammatory diseases (vulvovaginitis).
Combustiology: treatment of superficial and deep burns of II and IIIA degree, preparation of burn wounds for dermatoplasty.
Dermatology: treatment and prevention of pyodermia and dermatomycosis, foot mycosis, candidiasis of skin and mucous membranes.
Venereology: individual prophylaxis of sexually transmitted diseases (syphilis, gonorrhea, chlamydia, trichomoniasis, genital herpes, genital candidiasis).
Urology: treatment of acute and chronic urethritis and urethroprostatitis specific (chlamydia, trichomoniasis, gonorrhea) and nonspecific etiology.
Contraindications .
Individual intolerance to the drug.
It is not recommended to apply the drug in the form of a spray for irrigation of the throat and tonsils in children under 3 years of age in view of the risk of reactive laryngospasm.
Administration during pregnancy and lactation
Application of the drug during pregnancy and breast-feeding is possible if the expected benefits to a mother exceed the potential risk to a fetus and a baby. It is necessary to consult the doctor.
Before using the drug, if you are pregnant or plan to become pregnant, it is necessary to consult your doctor.
It is necessary to consult a doctor before using the drug during breastfeeding.
Directions for use and dosages
- Topically, externally.
- The drug is ready to use.
- Directions for use of the package with spray nozzle:
1. Remove the cap from the bottle. 2.
Remove the supplied spray nozzle from the individual packaging. 3.
3. 3. Attach the spray nozzle to the bottle.
Activate the spray nozzle by pressing again. - Notes on how to use the Vaginal Nozzle Package:
1. Remove the cap from the vial.
Take the included vaginal nozzle out of the individual packaging. 3.
3. Attach the vaginal nozzle to the vial without removing the urological applicator. - Directions for use of the package with a measuring cup:
To use the product as a gargle, the amount of product needed for one gargle should be measured with the measuring cup included in the package. - Otorhinolaryngology
- Adults and children
In maxillary sinusitis: during puncture the maxillary sinus is flushed with a sufficient amount of the drug.
If acute and chronic otitis externa: a dropper is placed into the external auditory canal to 5 drops of the drug 4 times a day or instead of putting drops into the external auditory canal a gauze turunda soaked in the drug is gently inserted 4 times a day. The course of treatment is 10 days. - Tonsillitis, pharyngitis, laryngitis:
- Children 3-6 years old: by a single squeeze on the head of the sprayer nozzle or 3-5 ml per rinse, 3-4 times a day;
- Children 7-14 years old: by pressing the head of the sprayer twice or 5-7 ml per rinse, 3-4 times a day;
- Children over 14 years of age and adults: by 3-4 times by pressing the head of the sprayer nozzle or 10-15 ml per rinse, 3-4 times a day.
Duration of therapy is from 4 to 10 days, depending on the time of remission. - Dentistry
- Adults and children
In case of stomatitis, gingivitis, periodontitis it is recommended to rinse the mouth cavity
10-15 ml of the drug 3-4 times a day. If it is impossible to rinse, local application of gauze or cotton swabs moistened with the drug solution is allowed. - Surgery, traumatology, combustiology
- Adults and children
In order to treat and prevent secondary wound infection the surface of the wound is irrigated with the drug solution.
Gauze tampons moistened with the drug solution are fixed on the wound surface.
If necessary, it is possible to tamponize the wound and/or fistulous passages during surgical manipulations.
Active drainage of wounds and/or cavities is possible. Daily consumption is up to 1 liter of the drug. - Obstetrics, gynecology
- Adults
Prevention and treatment of suppuration of postpartum traumas, perineal and vaginal wounds, postpartum infections: The drug is used in the form of vaginal irrigations before childbirth.
(5-7 days) and during labor (after each vaginal examination). In the postpartum period the drug is administered using tampons moistened with 50 ml of the drug, with further exposure of the tampon for 2 hours for 5 days. - At delivery of women by caesarean section the vagina is treated immediately before the operation, during the operation – the uterine cavity and incision, and in the postoperative period the tampons moistened with the drug are inserted into the vagina with exposure for 2 hours for 7 days.
- Treatment of inflammatory diseases is carried out by a course of 2 weeks by intravaginal administration of tampons with the drug, as well as by the method of drug electrophoresis.
- The complex treatment of inflammatory diseases in gynecology (vulvovaginitis): in the form of vaginal irrigations or the introduction of tampons soaked in the drug, with the exposure of 2 hours for 7-14 days (duration of treatment and the frequency of introduction is determined by the doctor).
- For convenience of vaginal irrigation it is recommended to use a vaginal nozzle. The content of the vial with the help of the vaginal nozzle is introduced into the vagina and perform irrigation.
- Children
Directions for use, duration of application and number of times of application are prescribed by the physician. - Dermatology
Adults and children
Treatment and prophylaxis of pyodermia and dermatomycosis, candidiasis of skin and mucous membranes, foot mycosis: the drug is applied to the affected skin area by wiping with sterile gauze tampons abundantly moistened with the drug. The drug is applied 3 times a day to the affected skin areas. - Venereology
- Adults
Prevention of sexually transmitted diseases: The drug is effective for 2 hours after sexual intercourse. - Use a urological applicator to insert the contents of the vial into the urethra for 2-3 min:
- Men: 2-3 ml of the drug;
- For women: inject 1-2 ml of the preparation into the urethra and 5-10 ml into the vagina (use of a vaginal tip is recommended for convenience).
- Treat the skin on the inner surfaces of the thighs, pubis, genitals. After the procedure is recommended not to urinate for 2 hours.
