Ascorbic acid, paracetamol, phenylephrine (Prostudox) powder lemon 5 g – [5 sachets]

A combined remedy, the action of which is due to its constituent components.

Paracetamol is an analgesic and antipyretic. Its mechanism of action is believed to be inhibition of prostaglandin synthesis, mainly in the central nervous system.

Paracetamol is a non-narcotic analgesic. It blocks cyclooxygenase (COX) only in the central nervous system (CNS), affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the lack of anti-inflammatory effect. Its lack of effect on prostaglandin synthesis in peripheral tissues explains its lack of negative effect on water-salt metabolism (sodium and water retention) and gastrointestinal (GI) mucosa.

Phenylephrine hydrochloride is a sympathomimetic agent whose action is aimed at stimulation of adrenoreceptors (mainly α-adrenoreceptors), which leads to reduction of nasal mucosal edema and facilitation of nasal breathing.

Ascorbic acid (vitamin C) replenishes the increased need for vitamin C during “colds” and flu, especially during initial stages of the disease. Components in the drug do not cause drowsiness and do not impair concentration.

Prostudox® provides effective relief from symptoms of colds and flu, such as fever, headache, chills, nasal congestion and pain while swallowing.

Prostudox® drug is not recommended for patients with:

– Hypersensitivity to paracetamol, phenylephrine, ascorbic acid (vitamin C) or any other component of the drug;

– Severe hepatic or renal dysfunction;

– arterial hypertension;

– Thyroid hyperfunction (including thyrotoxicosis);

– diseases of the blood system;

– Heart disease (with severe aortic stenosis, acute myocardial infarction, tachyarrhythmia);

– hyperplasia of the prostate gland;

– Diabetes mellitus and diseases associated with hereditary disorders of sugar absorption – each package contains about 3.5 g of sugar;

– Genetic absence of glucose-6-phosphate dehydrogenase;

– closed angle glaucoma;

– diseases accompanied by portal hypertension;

– concomitant use of tricyclic antidepressants, beta-adrenoblockers, monoamine oxidase inhibitors (MAOIs), including up to 14 days after their withdrawal;

– concomitant use of other paracetamol-containing drugs, decongestants, non-narcotic analgesics, non-steroidal anti-inflammatory drugs, drugs to relieve symptoms of “colds”, flu and nasal congestion, appetite regulators, amphetamine-like psychostimulants, barbiturates, antiepileptics, rifampicin, chloramphenicol (see section “Interaction with other medicines”)

– concomitant use of ethanol-containing drinks and medicinal products;

– Chronic alcoholism;

– sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, since it contains sucrose;

– under 18 years of age;

– pregnancy and during breastfeeding.

• The contents of one bag poured into a glass and fill it with hot water, stir until completely dissolved and, if desired, add sugar or honey to taste.
• Adults: take one bag every 4-6 hours, but no more than 4 bags in 24 hours.
• The drug is not recommended to take more than five days without medical advice. If symptoms persist you should consult a doctor.
• Do not exceed the indicated dose!
• You should use the lowest dose necessary to achieve the effect!
• Do not take simultaneously with other paracetamol-containing drugs, decongestants and drugs for cold and flu symptoms relief as well as with ethanol-containing drugs and drinks.
• If symptoms persist while taking the drug, you should consult a doctor.
• If you exceed the recommended dose of the drug, seek medical attention immediately, even if you feel well. Paracetamol overdose may cause hepatic failure.
• Special patient groups
• Patients with impaired renal or hepatic function
• Patients with impaired renal or hepatic function should consult their physician before using Prostudox®. Limitations associated with the use of drugs containing this combination of active ingredients in patients with impaired renal or hepatic function are mainly related to the content of paracetamol in the medicinal product.