Description
Ammifurin Pharmacodynamics
Ammifurin® is the sum of furocoumarins: isopympinellin, bergapten and xanthotoxin, isolated from the fruit of Ammi majus L. of the celery family Apiaceae.
Ammifurin® has a photosensitizing effect.
Indications
Used in adults for vitiligo, multiple and total baldness, psoriasis.
Contraindications
Intolerance to ultraviolet irradiation (UVI) and psoralen. Diseases accompanied by hypersensitivity to light (albinism, systemic lupus erythematosus).
In combination with UVA for the following diseases:
– tuberculosis;
– thyrotoxicosis;
– decompensated endocrine diseases;
– blood diseases;
– Liver diseases (hepatitis, cirrhosis);
– kidney diseases (nephritis);
– diseases of the cardiovascular system (chronic heart failure, hypertension II-III degree);
– diseases of the central nervous system (cachexia);
– Acute gastritis, gastric and 12 duodenal ulcer in the acute stage;
– pancreatitis;
– diabetes;
– Pregnancy and breastfeeding;
– cataracts;
– Multiple pigmented nevi;
– Benign and malignant tumors;
– Lactase deficiency, lactose intolerance, glucose-galactose malabsorption;
– under 18 years of age.
Dosage and administration
- The drug is prescribed in combination with ultraviolet irradiation (UVI).
The preparation (20 mg) is taken orally with milk, at a dose of 0.8 mg/kg, but not more than 80 mg (4 tablets) per dose, once 2 hours before the UVA. The course dose of the drug is 100-150 tablets (2-3 g). Repeated courses are carried out at intervals of 1-1.5 months. - In psoriasis treatments are carried out 4 times a week. UV exposure begins with 1/2 dose, gradually increasing to 5-6 biodoses, which corresponds (depending on the individual sensitivity of the patient to UV radiation), the duration of exposure from 1-2 minutes to 10-15 minutes. The total amount of radiation is 15-20 treatments.
- When vitiligo, blotchy and total baldness UVB is carried out 3 times a week (every other day) – 20-25 irradiation. A total of 4-6 courses are carried out.
