Description
Galavit Pharmacodynamics
Immunomodulatory drug with anti-inflammatory action.
The mechanism of action is associated with the ability to influence the functional and metabolic activity of macrophages. In inflammatory diseases reversibly (for 6-8 hours) inhibits excessive synthesis of tumor necrosis factor, interleukin-1 and other pro-inflammatory cytokines, reactive oxygen species by hyperactivated macrophages which determine the degree of inflammatory reactions, their cyclic pattern as well as severity of intoxication. Normalization of the functional state of macrophages leads to restoration of antigen-presenting and regulatory function of macrophages, reduction of autoaggression level.
The drug stimulates bactericidal activity of neutrophil granulocytes, increasing phagocytosis and increasing nonspecific resistance of the organism to infectious diseases.
The main pharmacological effects are observed within 72 h.
Indications
As an immunomodulator and anti-inflammatory agent in the treatment of immunodeficiency disorders in adults:
– Infectious intestinal diseases accompanied by intoxication and / or diarrhea;
– gastric and duodenal ulcers;
– viral hepatitis;
– Chronic recurrent diseases caused by the herpes virus;
– Diseases caused by human papillomavirus (HPV);
– Infectious-inflammatory diseases of the urogenital tract (urethritis of chlamydial and trichomonad etiology, chlamydial prostatitis, acute and chronic salpingoophoritis, chronic endometritis);
– Purulent inflammatory diseases of the pelvic organs (POPS);
– Postoperative rehabilitation of patients with uterine myoma;
– Complications of postoperative period in patients of reproductive age;
– Postoperative pyo-septic complications and their prevention (including cancer patients);
– Chronic recurrent furunculosis,
Contraindications
– pregnancy;
– lactation;
– Individual intolerance.
Dosage and administration
- Regimen dosage and duration of therapy set individually depending on the nature, severity and duration of the disease.
- For injections the preparation in powder form for solution for injection is diluted in 2 ml of water for injection or in 0.9% sodium chloride solution.
- Adults
In acute intestinal infections accompanied with diarrhea, the initial single dose is 200 mg once. Then the drug is administered in a dose of 100 mg 2 until relief of intoxication symptoms. It is possible to continue a further course of 100 mg at intervals of 72 hours. The course is 20-25 injections. - In gastric and duodenal ulcer in the acute period it should be given 2 days in doses of 200 mg once and then 100 mg at 72-hour intervals. The course of 15-25 injections. In the chronic period, 100 mg once daily for 5 days and then 100 mg at 72-hour intervals. The course of the preparation is 20 injections.
- In viral hepatitis of various etiologies in acute phase of the disease the initial dose is 200 mg once and then 100 mg 2 times until relief of symptoms of intoxication and inflammation. The subsequent course of therapy is continued in a dose of 100 mg at intervals of 72 hours. The course is 20-25 injections.
- In chronic recurrent herpes infection, the drug is prescribed in a dose of 100 mg daily for 5 injections, followed by 100 mg every other day for 15 injections.
- In cases of diseases caused by HPV, the drug is prescribed for 5 days in doses of 100 mg once a day, and then in doses of 100 mg every other day. The course is 20 injections.
- In cases of urogenital infections (chlamydial and trichomonad urethritis, chlamydial prostatitis), the drug is prescribed 100 mg 2 for 1 day, then the drug is changed to 100 mg every other day. The course is 10-15 injections, depending on the severity of the pathological process.
- In salpingo-oophoritis, endometritis in the acute period the drug is prescribed for 2 days at 200 mg once and then 100 mg at 72-hour intervals. The course is 20 injections. During the chronic period the drug is prescribed for 5 days in doses of 100 mg once and then 100 mg every 72 hours. The course consists of 20 injections.
- In acute and chronic STIs in the acute period, the drug is prescribed for 1 day at 200 mg once daily, then for 3 days at 100 mg daily, and then 100 mg every other day for 5 injections. The course is 20 injections. In chronic phase the preparation is prescribed for 5 days in dose 100 mg once daily, 100 mg every 72 hours thereafter. The course is 20 injections.
- For postoperative rehabilitation of patients with uterine myoma and with complications of the postoperative period in patients of reproductive age, the drug is prescribed for 5 days in 100 mg once daily and then in 100 mg every other day. The course is 15 injections.
- For prevention and treatment of surgical complications during the preoperative and postoperative periods (including in cancer patients), the drug is prescribed 100 mg 1 time/ 5 injections before surgery, 100 mg daily and 5 injections with an interval of 72 hours after surgery.
