Description
Bismuth tricalium dicitrate Pharmacodynamics
Gastroprotective and antiulcer with bactericidal activity against Helicobacter pylori. It also has anti-inflammatory and astringent action.
In acidic environment of the stomach insoluble bismuth oxychloride and citrate are precipitated, chelated compounds with protein substrate are formed in the form of a protective film on the surface of ulcers and erosions. Thus, the drug forms a protective layer, which for a long period of time protects the affected areas of the mucous membrane from the effects of aggressive factors. By increasing the synthesis of prostaglandin E, mucus formation and hydrocarbonate secretion, it stimulates the activity of cytoprotective mechanisms, increases resistance of gastrointestinal mucosa to pepsin, hydrochloric acid, enzymes and salts of bile acids. Leads to the accumulation of epidermal growth factor in the defect area. Reduces the activity of pepsin and pepsinogen.
Indications
– Functional dyspepsia not associated with organic diseases of the gastrointestinal tract;
– Chronic gastritis and gastroduodenitis in the acute phase, including those associated with Helicobacter pylori;
– gastric and duodenal ulcer in the acute phase, including those associated with Helicobacter pylori;
– Irritable bowel syndrome, mostly with diarrhea symptoms.
Contraindications
– Increased individual sensitivity to the drug components;
– pregnancy;
– Breast-feeding period;
– Taking drugs containing bismuth;
– Chronic renal failure;
– Childhood under 4 years.
Pregnancy and lactation:
Bismuth tricalium dicitrate is contraindicated for use in pregnant women. If it is necessary to apply the drug during lactation, breastfeeding should be discontinued.
Dosage and administration method
- Inside. The duration of treatment and dosage of the drug shall determine the attending physician individually for each patient, depending on the nature of the disease.
- Adults and children over 12 years of age – 1 tablet 4 times a day, 30 minutes before a meal (breakfast, lunch, dinner) and at night, or 2 tablets 2 times a day for 30 minutes before a meal (breakfast, dinner).
- Children aged 8 to 12 years are prescribed 1 tablet 2 times a day, 30 minutes before a meal (breakfast and dinner).
- The dose for children aged 4 to 8 years is 8 mg/kg/day (1-2 tablets/day, respectively), depending on the body weight of the child. The daily dose should be as close as possible to the calculated dose (8 mg/kg/day). Tablets are taken 30 minutes before a meal with plenty of water.
- It is recommended to swallow the tablet whole, without chewing and crushing, with plenty of water. It is not recommended to wash down the tablets with milk. The duration of treatment is usually from 4 to 8 weeks. After the end of taking the drug, it is not recommended to take medicines containing bismuth (e.g., Vicalin, Vikair) for 2 months.
- For eradication of Helicobacter pylori it is reasonable to use bismuth tricalium dicitrate in combination with antibacterial drugs that have anti-Helicobacter activity.
- If there is no improvement during treatment, you should consult a doctor. Use the drug only according to the method of administration and in the doses described in the instructions. If necessary, please consult your physician before using the drug.
