Description
Sonnovan Pharmacodynamics
A synthetic analog of the pineal body hormone (epiphysis); has an adaptogenic, sedative and hypnotic effect. Normalizes circadian rhythms. Increases the concentration of gamma-aminobutyric acid (GABA) and serotonin in the midbrain and hypothalamus, changes the activity of pyridoxal kinase, involved in the synthesis of GABA, dopamine and serotonin. Regulates the sleep-wake cycle, daily changes in locomotor activity and body temperature, has a positive effect on the intellectual and mental functions of the brain, and on the emotional-personal sphere. Facilitates organization of the biological rhythm and normalization of night sleep. Improves sleep quality, speeds up falling asleep, regulates neuroendocrine functions. Adapts the organism of weather-sensitive people to changes in weather conditions.
Indications
In disorders of sleep, including those caused by a violation of the rhythm of “sleep-wake”, such as desynchronosis (rapid change of time zones).
Contraindications .
Hypersensitivity to the components of the drug, autoimmune diseases, liver failure, severe renal failure, children under 18 years of age.
Pregnancy and lactation:
The drug is contraindicated for use in pregnancy and during breast-feeding.
Dosage and administration method.
- Inside.
- In violation of sleep, desynchronosis – 1 tablet once a day for 30-40 minutes before sleep.
- When used as an adaptogen when changing time zones – 1 day before the flight and the next 2-5 days – 1 tablet 30-40 minutes before bedtime. The maximum daily dose is 6 mg.
- Elderly patients
- With age there is a decrease of melatonin metabolism that should be taken into consideration when choosing a dosage regimen for elderly patients. Taking this into account, elderly patients may take the drug 60-90 minutes before sleep.
- Renal failure
- The effect of various degrees of renal failure on the pharmacokinetics of melatonin has not been studied, therefore melatonin should be used with caution in these patients. In patients with severe renal insufficiency, the use of the drug is not recommended.
