Description
Slabicap Pharmacodynamics
Active substance – sodium picosulfate is a laxative of triarylmethane group. As a local laxative, sodium picosulfate after bacterial cleavage in the large intestine has a stimulating effect on the mucosa of the large intestine, increasing peristalsis, contributes to accumulation of water and electrolytes in the large intestine. This leads to stimulation of the act of defecation, reduction of evacuation time and softening of stools.
Sodium picosulfate, being a laxative acting at the level of the large intestine, stimulates the natural process of evacuation of contents from the lower parts of the gastrointestinal tract. Therefore, sodium picosulfate has no effect on digestion or absorption of caloric foods or essential nutrients in the small intestine.
Indications
Atonic constipation. Stool regulation (hemorrhoids, proctitis, anal fissures). Preparing for surgery, instrumental and radiological examinations.
Contraindications .
Hypersensitivity to sodium picosulfate and other components of the drug.
Intestinal obstruction or obstructive bowel disease; acute inflammatory bowel disease and acute abdominal diseases (including acute appendicitis, ulcerative colitis, peritonitis); severe abdominal pain accompanied by nausea, vomiting and fever, which may indicate acute inflammatory diseases, severe dehydration; sucrose intolerance, sucrose/isomaltose deficiency, glucose-galactose malabsorption (sorbitol is included).
Pregnancy. Childhood under 4 years of age.
Caution
Use with caution in elderly patients with hypokalemia, increased concentration of magnesium in the blood and in patients with asthenia.
The drug is used in patients with severe renal insufficiency (according to section “Special indications”) only under medical supervision. Administration during pregnancy and breast-feeding
It is not recommended to use the drug Slabicap during pregnancy due to the lack of clinical trials.
Clinical data show that neither the active metabolite BGPM nor its glucuronides penetrate into the breast milk. Thus, the drug Slabicap can be used during breast-feeding.
Directions for use and dosages.
Inside.
The following regimen is recommended:
Adults and children over 10 years of age: 13-27 drops (corresponding to 5-10 mg of sodium picosulfate) per day.
Children from 4 to 10 years of age (as prescribed by a physician only): 7-13 drops (corresponding to 2.5-5 mg of sodium picosulfate) per day.
It is recommended to start with the lowest dose. In order to achieve regular stools, the dose may be increased to the maximum recommended dose. The maximum recommended daily dose should not be exceeded.
In order to obtain a laxative effect in the morning, the drug Slabicap should be taken the night before. After using the drug Slabicap bowel emptying occurs after 10-12 hours. The drug can be used both with and without liquid.
The drug Slabicap should not be taken daily without medical advice for more than 10 days.
