Description
Orvis Flu Pharmacodynamics
A combination drug containing paracetamol, pheniramine and ascorbic acid.
Paracetamol – non-narcotic analgesic, blocks cyclooxygenase, mainly in the central nervous system, affecting the centers of pain and thermoregulation; has analgesic and antipyretic effects
Pheniramine is a blocker of H1-histamine receptors, it reduces rhinorrhea and lacrimation, eliminates spasticity, edema and hyperemia of the nasal cavity mucosa, nasopharynx and sinuses.
Ascorbic acid is involved in the regulation of redox processes, carbohydrate metabolism, blood coagulation, tissue regeneration, the synthesis of steroid hormones, reduces vascular permeability, reduces the need for vitamins B1, B2, A, E, folic acid, pantothenic acid. Improves tolerance to paracetamol and prolongs its effect (associated with prolongation of the elimination half-life (T1/2)).
Indications
Used in acute respiratory infections, acute respiratory viral infections (ARI), nasopharyngitis (runny nose), influenza to relieve the following symptoms:
– elevated body temperature;
– chills;
– headache;
– nasal congestion;
– rhinorrhea;
– lacrimation;
– sneezing;
– muscle and joint pain
Contraindications
Hypersensitivity to paracetamol, ascorbic acid, pheniramine or any of the excipients.
Pregnancy and breast-feeding period.
Ulcerative lesions of the gastrointestinal tract (in the acute phase). Liver failure.
Closed-angle glaucoma.
Urinary retention associated with prostate disease and impaired urination.
Portal hypertension.
Alcoholism.
Phenylketonuria.
Deficiency of the enzyme glucose-6-phosphate dehydrogenase.
Age under 15 years of age.
Dosage and administration
- Inside 1 sachet 2-3 times a day.
- Before using the contents of a single sachet dissolved in a glass (200 ml) of hot water (50-60 ° C).
- If necessary, add sugar.
- ORVIS® Flu can be taken at any time of the day, but the best effect is achieved by taking the drug at bedtime.
- Maximal daily dose of paracetamol is 4 g (8 sachets) for body weight more than 50 kg.
- The interval between doses of the drug should be at least 4 hours.
- In patients with impaired renal function (creatinine clearance <10 ml/min) the interval between doses of the drug must be at least 8 hours.
- Maximum duration of treatment is 5 days.
- If there is no relief of symptoms within 5 days after initiation of the drug, elevated body temperature persists or after initial decrease it suddenly increases again, it is necessary to consult a physician.
