Description
Nuralgon Pharmacodynamics
A combination drug, the action of which is due to its constituent components.
Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID), has analgesic, anti-inflammatory, antipyretic effects. Inhibiting cyclooxygenase (COX) 1 and 2, disrupts the metabolism of arachidonic acid, reduces the number of prostaglandins (mediators of pain, inflammation and hyperthermia), both in the focus of inflammation and in healthy tissues, inhibits the exudative and proliferative phases of inflammation.
Paracetamol non-selectively blocks COX, mainly in the central nervous system, has little effect on water-salt metabolism and the mucosa of the gastrointestinal tract (GIT). It has analgesic and antipyretic effects. In inflamed tissues, peroxidases neutralize the effect of paracetamol on COX 1 and 2, which explains the low anti-inflammatory effect.
The efficacy of the combination is higher than that of the individual components. It relieves arthralgia at rest and during movement, reduces morning stiffness and joint swelling, helps to increase the amount of movement.
Indications
– Symptomatic treatment of infectious and inflammatory diseases (colds, flu), accompanied by fever, chills, headache, pain in muscles and joints, sore throat;
– myalgia;
– neuralgia;
– back pain;
– joint pain, pain syndrome in inflammatory and degenerative diseases of the musculoskeletal system;
– Pain from contusions, sprains, dislocations, fractures;
– Post-traumatic and post-operative pain syndrome;
– toothache;
– algodysmenorrhea.
The drug is intended for symptomatic therapy, to reduce pain and inflammation at the time of use, does not affect the progression of the disease.
Contraindications
– Individual hypersensitivity to the components of the drug (including other NSAIDs);
– gastrointestinal erosive-ulcer disease (including gastric and duodenal ulcer, Crohn’s disease, ulcerative colitis) or ulcer bleeding in active phase or in anamnesis (two or more confirmed episodes of ulcer disease or ulcer bleeding)
– Cerebrovascular or other bleeding;
– hemophilia or other bleeding disorders (including hypocoagulation), hemorrhagic diathesis, intracranial hemorrhage;
– severe renal insufficiency (creatinine clearance (CK) less than 30 ml/min);
– complete or incomplete combination of bronchial asthma, recurrent nasal and paranasal sinus polyposis and intolerance to acetylsalicylic acid or other NSAIDs (including anamnesis);
– severe heart failure (NYHA class IV);
– decompensated heart failure;
– optic nerve damage;
– Genetic absence of glucose-6-phosphate dehydrogenase;
– blood system disorders;
– period after coronary artery bypass grafting;
– progressive renal disease;
– severe hepatic insufficiency or active liver disease;
– confirmed hyperkalemia;
– Pregnancy over 20 weeks;
– Childhood under 18 years of age.
Dosage and administration
- Orally (before or 2-3 hours after a meal), without chewing, with plenty of water.
- One tablet three times a day. The maximum daily dose is 3 tablets.
- Duration of treatment no more than 3 days as an antipyretic and no more than 5 days as an analgesic. Continued treatment with the drug is possible only after consultation with the doctor.
- If after treatment no improvement or worsening of symptoms or appearance of new symptoms occurs, it is necessary to consult a doctor. Use the drug only according to the indications, the route of administration and the doses stated in these instructions.
