Description
Nifuroxazid-Eco Pharmacodynamics
Nifuroxazide is an antimicrobial agent derived from nitrofuran. It blocks activity of dehydrogenases and inhibits respiratory chain, tricarboxylic acid cycle and a number of other biochemical processes in a microbial cell. It destroys the membrane of the microbial cell and reduces the production of toxins by microorganisms. Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp, Shigella spp; Clostridium perfringens, Vibrio cholera, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp. Weakly sensitive to nifuroxazide: Citrobacter spp, Enterobacter cloacae and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp, Proteus mirabilis, Providencia spp, Pseudomonas spp. It does not disturb the balance of intestinal microflora. At acute bacterial diarrhea it restores intestinal eubiosis. In case of infection with enterotropic viruses prevents the development of bacterial superinfection.
Indications
Acute bacterial diarrhea without a deterioration of the general condition, fever, intoxication.
Contraindications
Hypersensitivity to nifuroxazide, to nitrofuran derivatives and other components of the drug, pregnancy, newborn period (less than 1 month), prematurity, sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
Use in pregnancy and during breastfeeding:
No teratogenic effects have been observed in animal studies. However, as a precautionary measure, it is not recommended to take nifuroxazide during pregnancy. During the lactation period it is possible to continue breastfeeding in case of a short course of treatment with the drug. It is necessary to consult a physician.
Dosage and administration
- The drug is used orally.
- Shake vial thoroughly before use until homogeneous suspension is obtained.
- Children from 1 to 6 months: 100 mg (2.5 ml of suspension) 2-3 times a day (interval between doses of 8-12 hours).
- Children from 6 months to 3 years of age: 100 mg (2.5 ml of suspension) 3 times a day (interval between doses of 8 hours).
- Children from 3 to 6 years of age: 200 mg (5 ml of suspension) 3 times a day (interval between doses of 8 hours).
- Children from 6 to 18 years of age: 200 mg (5 ml of suspension) 3 to 4 times a day (the interval between doses is 6-8 hours).
- Adults: 200 mg (5 ml of suspension) 4 times a day (interval between doses is 6 hours).
- For dosing use a measuring spoon, cup or dosing pipette of 5 ml with graduation of 2.5 ml.
- Duration of treatment course is 5-7 days, but not more than 7 days. If during the first 3 days of treatment there is no improvement, you should consult a doctor. Use the drug only according to the method of use and in those doses that are specified in the instructions. If necessary, please consult a physician before using the drug.
