Description
Nifuroxazide-Vertex Pharmacodynamics
Nifuroxazide is an antimicrobial agent, a nitrofuran derivative. It blocks activity of dehydrogenases and inhibits respiratory chains, tricarboxylic acid cycle and a number of other biochemical processes in a microbial cell. It destroys the membrane of the microbial cell and reduces the production of toxins by microorganisms. Highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp., Shigella spp.; Clostridium perfringens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp. Weakly sensitive to nifuroxazide: Citrobacter spp., Enterobacter cloacae and Proteus indologenes. Resistant to nifuroxazide: Klebsiella spp., Proteus mirabilis, Providencia spp., Pseudomonas spp.
Nifuroxazide does not disturb the balance of intestinal microflora. In acute bacterial diarrhea it restores intestinal eubiosis. In case of infection with enterotropic viruses it prevents development of bacterial superinfection.
Indications
Acute bacterial diarrhea without a deterioration of the general condition, increased body temperature, intoxication.
Contraindications
– Hypersensitivity to nifuroxazide, nitrofuran derivatives or other components of the drug;
– pregnancy;
– children under 3 years of age (for this dosage form);
– sucrose/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
Administration during pregnancy and lactation
Pregnancy
No teratogenic effect has been shown in animal studies. However, as a precautionary measure, it is contraindicated to take Nifuroxazide VERTEKS during pregnancy.
Period of breastfeeding
During the period of lactation, it is possible to continue breastfeeding in case of a short course of treatment with the drug. Consult a physician.
Dosage and administration
- Inside.
- The capsule should be swallowed whole with a small amount of water.
100 mg capsules - Children from 3 to 6 years of age
2 capsules (200 mg) 3 times a day (8 hours between doses). - Children 6 to 18 years of age
2 capsules (200 mg) 3 to 4 times a day (interval between doses of 6-8 hours). - Adults
2 capsules (200 mg) 4 times a day (interval between doses of 6 hours). - Capsules 200 mg
Children 3 to 6 years of age
1 capsule (200 mg) 3 times a day (8 hours’ interval between doses). - Children 6 to 18 years of age
1 capsule (200 mg) 3 to 4 times a day (interval between doses of 6-8 hours). - Adults
1 capsule (200 mg) 4 times a day (interval between doses of 6 hours). - The course of treatment is 5-7 days, but no more than 7 days. If during the first three days of treatment there is no improvement, you should consult a doctor.
- Use the drug only according to the method of use and in those doses that are listed in the instructions. If necessary, please consult your doctor before using Nifuroxazide VERTEX.
