Description
Levofloxacin Pharmacodynamics
Levofloxacin is the L-isomer of the racemic medicinal substance ofloxacin. The antibacterial activity of ofloxacin mainly refers to the L-isomer.
As an antibacterial drug of fluoroquinolones class, levofloxacin blocks DNA-hymerase (topoisomerase II) and topoisomerase IV, disrupts superspiralization and crosslinking of DNA (deoxyribonucleic acid) breaks, inhibits DNA synthesis, causes profound morphological changes in cytoplasm, cell wall and membranes.
Indications
– Treatment of superficial bacterial eye infections caused by susceptible microorganisms in adults and children over 1 year of age.
– Prophylaxis of complications after surgical and laser operations on the eye.
Contraindications
Hypersensitivity to levofloxacin or to any of the components of the medicinal product, other quinolones.
If you have one of the listed diseases, always consult your doctor before taking the drug.
Caution:
Childhood.
If the drug is used to treat children, be sure to consult a doctor before taking the drug.
Dosage and administration
- Topically, into the affected eye. Duration of treatment course is determined by the severity of the condition, its clinical and bacteriological features. Average duration of therapy is 5 days.
- One to two drops in the affected eye(s) every two hours up to eight times a day during the waking period for the first two days, then four times a day from days 3 to 5.
- When several drugs are used, the interval between instillations should be at least 15 minutes.
