Description
Levomycetin Pharmacodynamics
The active ingredient of the drug is chloramphenicol – a broad-spectrum antibiotic with high antibacterial activity against the causative agent of wound infection and various forms of purulent inflammatory processes. Chloramphenicol is a bacteriostatic antibiotic that disrupts protein synthesis in a microbial cell (having good lipophilicity, it penetrates through the cell membrane of bacteria and binds back to 50S subunit of bacterial ribosomes, where amino acid transfer to growing peptide chains is delayed, which leads to disruption of protein synthesis). Active against most strains of gram-positive and gram-negative microorganisms resistant to penicillin, tetracyclines, sulfonamides. Promotes cleansing and healing of burn purulent wounds and trophic ulcers, accelerates epithelialization.
Indications
Bacterial skin infections caused by susceptible microorganisms, including infected burns (superficial and limited deep), bedsores, trophic ulcers, furuncles.
Contraindications
Individual intolerance, bone marrow hematopoiesis inhibition, acute intermittent porphyria, glucose-6-phosphate dehydrogenase deficiency, hepatic and renal insufficiency, skin diseases (psoriasis, eczema, fungal lesions), pregnancy, breast-feeding, newborn period (less than 4 weeks).
Caution.
Early childhood as well as patients treated earlier with cytostatic drugs or radiation therapy.
Dosage and administration
- Outwardly, the damaged area is treated with a cotton swab dipped in the solution, several times a day.
