Description
Disol Pharmacodynamics
Combined saline solution for rehydration and detoxification. Restores water-electrolyte balance and acid-base state in the body in case of dehydration. Prevents the development of metabolic acidosis, increases diuresis. It has plasma exchange, detoxifying, rehydrating effect.
Indications
Dehydration, hyperkalemia, intoxication due to dehydration (cholera, acute dysentery, food toxicosis).
Contraindications .
Renal and heart failure.
Caution
The drug should be used with caution in hypokalemia.
Administration during pregnancy and lactation
Administration during pregnancy is possible only in case of
when the assumed benefit for a mother exceeds the potential risk for a fetus.
Breast-feeding should be avoided during the period of drug administration because of absence of corresponding clinical data.
Dosage and administration regimen
- Intravenously (by stream and drop), under control of the laboratory indices (electrolytes Na+, K+, Cl-, acid-base state of blood). The ratio of injected fluid to diuresis is determined every 6 hours. During 1 hour the drug is administered by trickle, then trickle administration is replaced by dropwise administration for 24-48 hours at the rate of 40-120 drops/minute. Before injection the solution is heated to 36-38 °C. The solution is administered in the amounts necessary to restore the volume of fluid lost in the faeces, vomit, urine, sweat.
- In severe forms of diseases (hypovolemic infectious-toxic shock, decompensated metabolic acidosis, anuria) begin with a stream administration of the drug with subsequent transition to drip administration.
- In milder forms of diseases (intoxication and dehydration of the body, metabolic acidosis, oliguria) the drug may be limited to drip administration. After elimination of hyperkalemia further water-salt therapy is carried out with Trisol, Acesol or Chlosol solutions.
- In severe forms of diseases (hypovolemic infectious-toxic shock, decompensated metabolic acidosis, anuria) begin with trickle administration of the drug with subsequent transition to drip.
- In milder forms of diseases (intoxication and dehydration, metabolic acidosis, oliguria) the drug may be limited to drip administration.
- After elimination of hyperkalemia further water-salt therapy is carried out with Trisol, Acesol or Chlorosol solutions.
