Description
Detravenol Pharmacodynamics
The drug is a purified micronized flavonoid fraction,
consisting of diosmin and other flavonoids in terms of hesperidin. This combination has venotonic and angioprotective properties. It reduces venous distensibility and venous stasis, in the microcirculation – reduces capillary permeability and increases their resistance, improves indices of venous hemodynamics. It affects the following venous plethysmographic parameters: venous capacity, venous distensibility, time of venous emptying. The optimal effect is achieved when taking 1000 mg. The drug increases venous tone by reducing the time of venous emptying. In patients with signs of a pronounced impairment
increased capillary resistance is noted in patients with signs of a pronounced microcirculatory disturbance.
The efficacy of the drug with respect to the indices of venous hemodynamics in the treatment of chronic diseases of the lower limbs veins, as well as in the treatment of hemorrhoids has been demonstrated.
Indications
Therapy of symptoms of chronic venous diseases (elimination and relief of symptoms).
Therapy of symptoms of venous and lymphatic insufficiency:
– pain;
– cramps of the lower extremities;
– Feeling of heaviness and expansion in the legs;
– Leg fatigue.
Therapy of manifestations of venous-lymphatic insufficiency:
– edema of the lower extremities;
– trophic changes in the skin and subcutaneous
skin and subcutaneous tissue;
– venous trophic ulcers.
Symptomatic therapy for acute and chronic hemorrhoids.
Contraindications .
– Hypersensitivity to the components of the drug;
– Breast-feeding period (experience of use is limited).
Application during pregnancy and lactation.
Pregnancy
Experiments on animals have not revealed teratogenic effects.
Up to now, there have been no reports of adverse reactions when using
the drug in pregnant women.
Period of breast feeding
Because of lack of data concerning penetration of the drug into breast milk, it is not recommended for women during breast feeding period.
Effect on reproductive function
Studies of reproductive toxicity showed no effect on reproductive function in rats of either sex.
Dosage and administration method
- Orally.
- The recommended dose for venous-lymphatic insufficiency is 2 tablets per day, preferably in the morning, with meals.
- The duration of treatment may be several months (up to 12 months). In case of recurrent symptoms, the treatment course may be repeated upon the doctor’s recommendation.
- The recommended dose for acute hemorrhoids – 6 tablets per day (3 tablets in the morning and 3 tablets in the evening) for 4 days, then 4 tablets per day (2 tablets in the morning and evening) for the next 3 days.
- The recommended dose for chronic hemorrhoids is 2 tablets per day.
