Description
Actitropil Pharmacodynamics
It is a nootropic medicine with a pronounced anti-amnesic effect, direct activating effect on the integrative activity of the brain, it contributes to memory consolidation, improves attention concentration and mental performance, facilitates the learning process, increases the speed of information transfer between the brain hemispheres, increases the resistance of brain tissue to hypoxia and toxic effects, has anticonvulsant and anxiolytic effects, regulates the processes of activation and inhibition of the central nervous system, inhibits the nervous system.
It has a positive effect on metabolic processes and the blood circulation of the brain, stimulates the redox processes, increases the energy potential of the body through the utilization of glucose, and improves the regional blood circulation in the ischemic brain areas. It increases the content of noradrenaline, dopamine and serotonin in the brain, does not affect the content of GABA, binds neither to GABA nor GABA receptors, does not affect significantly the spontaneous bioelectrical activity of the brain.
It has no effect on respiration and cardiovascular system, shows unexpressed diuretic effect, has anorexigenic activity when used as a course.
Its stimulating effect is shown in its ability to produce a moderately pronounced effect on motor reactions, to increase physical performance, a pronounced antagonism to the cataleptic effect of neuroleptics, as well as to decrease the intensity of the hypnotic effect of ethanol and hexenal.
Psychostimulatory action prevails in the ideational sphere.
Moderate psychostimulatory effect of the drug is combined with anxiolytic activity, improves the mood and has some analgesic effect, raising the threshold of pain sensitivity.
Adaptogenic effect is manifested in increased resistance to stress in conditions of excessive mental and physical exertion, fatigue, hypokinesia and immobilization, at low temperatures.
Against the background of admission marked improvement of vision, which is manifested in an increase in acuity, brightness and visual fields.
Improves blood flow to the lower extremities.
It stimulates the production of antibodies in response to the introduction of the antigen, which indicates its immunostimulatory properties, but at the same time it does not contribute to the development of the immediate hypersensitivity type and does not change the allergic inflammatory reaction of the skin, caused by the introduction of a foreign protein.
During the course of application there is no development of drug dependence, tolerance and “withdrawal syndrome”.
It has action from single dose, which is important when using the drug in ex-tremal conditions.
It has no teratogenic, mutagenic, carcinogenic and embryotoxic properties. Toxicity is low, lethal dose in an acute experiment is 800 mg/kg.
Indications
– CNS diseases of various genesis, especially those associated with vascular diseases and disorders of metabolic processes in the brain, intoxication (in particular, in post-traumatic states and phenomena of chronic cerebrovascular insufficiency), accompanied by deterioration of intellectual and mental functions, decreased motor activity;
– Neurotic conditions, manifested by lethargy, increased exhaustion, decreased psychomotor activity, impaired attention, poor memory;
– Learning disorders;
– Obesity (of alimentary and constitutional genesis);
– Prevention of hypoxia, increased resistance to stress, correction of the functional state of the body in extreme conditions of professional activity in order to prevent the development of fatigue and to improve mental and physical performance;
– Chronic alcoholism (to reduce symptoms of asthenia, intellectual and mental disorders).
Contraindications .
– Hypersensitivity to the active substance and / or any excipient of the drug;
– Pregnancy;
– Breast-feeding period;
– Childhood under 18 years of age (safety and efficacy of the drug have not been established).
Caution
Patients with severe organic lesions of the liver or kidneys, severe arterial hypertension, with significant atherosclerosis, who have previously suffered from panic attacks, acute psychotic states with psychomotor agitation – due to possible exacerbation of anxiety, panic, hallucinations and delirium, as well as patients who are prone to allergic reactions to nootropics of pyrro-leadone group.
Administration during pregnancy and lactation
It should not be administered during pregnancy and breast-feeding period because of lack of clinical trials data.
How to use and dosages.
- Inside.
Take immediately after a meal. The dose and duration of treatment should be determined by the doctor. Doses vary according to the patient’s condition. The average single dose is 150 mg (100 to 250 mg); the average daily dose is 250 mg (200 to 300 mg). The maximum tolerated dose is 750 mg/day. It is recommended that a daily dose of up to 100 mg should be taken once in the morning, and over 100 mg should be divided into 2 doses. The duration of treatment may vary from 2 weeks to 3 months, on average 30 days. If necessary, the course may be repeated in 1 month. - To increase the performance capacity, 100 to 200 mg once in the morning hours, for 2 weeks (for athletes – 3 days).
- The recommended duration of treatment for patients with alimentary-constitutional obesity is 30 to 60 days at a dose of 100 to 200 mg once a day (in the morning hours). It is not recommended to take the drug later than 3 p.m.
